Poster Session : PS-1543 ; COPD : Clinical Features and Prognostic Factors of the Patients Who Hospitalized Due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease = Poster Session : PS-1543 ; COPD : Clinical Features and Prognostic Factors of the Patients Who Hospitalized Due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease

다국어 초록 (Multilingual Abstract)

Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are important causes of hospital admission and mortality. We investigated the clinical features of hospitalized patients with severe AECOPD and evaluated prognostic factors associated the readmission or mortality due to re-exacerbation of COPD within 6 months. Methods: The prospective study was enrolled 314 patients who hospitalized with severe AECOPD. And we collected demographic, clinical and laboratory findings at admission. Lung function was evaluated using the COPD assessment test (CAT) questionnaire, the modified Medical Research Council (mMRC) dyspnea scale, and spirometry in the stable state. Results: The mean age was 72.2 ± 9.4 years (76.4% of male), and the rate of readmission within 6 months was 45.2% and mortality rate was 16.6%. When multivariate analysis was performed by using the significant variables, age (P < 0.001), CAT score (P < 0.001), old pulmonary tuberculosis (P = 0.003), initial PaO2 (P = 0.026), hemoglobin (P = 0.009), albumin (P = 0.005) and CRP at discharge (P < 0.001) were significantly associated with mortality. And also CAT score (P < 0.001), diabetes mellitus (P = 0.030) and CRP at discharge (P = 0.004) were significantly associated with readmission. In receiver operating characteristic curves, CRP at discharge than CAT score showed a good accuracy to predict the mortality. But CAT score showed good accuracy to predict readmission due to severe AECOPD. Conclusions: CRP at discharge as well as CAT score was significantly associated with both mortality and readmission due to AECOPD.