가토 대뇌피질에 Cephalosporins의 뇌피질 국소 도포가 뇌피질도에 미치는 영향 = The Effect of Topical Application of Cephalosporins on the Rabbit Cerebral Cortex

다국어 초록 (Multilingual Abstract)

Several of the newer broad-spectrum, potent antibiotics are currently being used for the treatment of meningitis, ventriculitis and shunt-tract infection. The risk of complications following intrathecal administration of some of this newer antibiotics varies considerably. Possible complications of immediate or delayed seizure, cortical electric depression, radiculopathy, transverse myelopathy, and arachnoiditis after intrathecal or intraventricular administration must be weighed against the potential value of this route. These risks may influence the therapeutic management of a specific clinical situation.
The author studied the effect of the first generation of cephalosporins (cepalothin, cefazolin, cephradine, cephapirin), the second generation of cephalosporins(cefamandole, cefmetazole), and the third generation of cephalosporins(cefotaxime, ceftriaxone, cefotetan), on electrocortical activity of cerebral cortex.
The results are as follows :
1) The topical application of cephalothin, cefazolin, cephapirin 8㎎/㎖ shows electrocortical spike activity. In higher concentration, each cases show intense electrocortical spike activity. The topical application of cephradine 100㎎/㎖ shows electrocortical spike activity and in higher concentration, electrocortical spike activity continued.
2) The topical application of cefamandole 64㎎/㎖ shows electrocortical spike activity first and that of cefmetazole 100㎎/㎖ shows electrocortical spike activity and in higher concentration of each cases, intense electrocortical spike activity continued.
3) The topical application of cefotaxime 16㎎/㎖ shows electrocortical spike activity and that of ceftriaxon 200㎎/㎖ and cefatetan 100㎎/㎖ shows mild electrocortical spike activity. In higher concentration of each cases, electrocortical spike activity contiuned.
In conclusion, the degrees of epileptogenic effect was most severe in the first generation of cephalosporins and the second generation of cephalosporins and the third generation of cephalosporins on the decreasing order.