경피흡수를 위한 케토롤락 하이드로겔의 제제설계 및 평가 = Formulation Design and Evaluation of Ketorolac Tromethamine Hydrogel for Transdermal Delivery System

다국어 초록 (Multilingual Abstract)

Ketocolac tromethamine(KT) is a nonsteroidal agent with potent analgesic and moderate anit-inflammatory activity. The lipid-water partition coefficient of KT was evaluated and KT gel was formulated as a gel containing different pH, different concentrations of polymer (poloxamer 407, carbopol 941), propylene glycol, ethanol and various enhancers. The resulting KT gels were evaluated with respect to their viscosity, in vitro drug permeation rate through hairless mouse skin and stability. In n-octanol and chloroform, the lipid-water partition coefficient of KT was the highest at pH 4 phosphate buffer. The apparent viscosity of KT gel increased with an increase in gel pH, polymer and enhancer concentration. But the apparent viscosity of KT gel decreased with an increase in ethanol concentration. The permeation rate of KT through hairless mouse skin from gels different pH was maximum at pH 4 which is close to KT pK_a 3.54. The permeation rate decreased with an increase in polymer, propylene glycol concentration. But the permeation rate increased with an increase in ethanol. The increase of drug concentration from 1 to 3% induced linear increase in permeation rate. The best enhancer was the combination of Labrasol^??, Transcutol^??, oleic acid and l-menthol. th the accelerated stability test(25, 40 and 50℃), pH 5 gel was most stable and pH 4 gel was most unstable for 90 days.