광기능성 Ni-Ti-O 나노튜브의 항균성 평가 = Evaluation of the antimicrobial activity of the photofunctionalized Ni-Ti-O nanotubes

국문 초록 (Abstract)

Ni-Ti-O 나노튜브는 낮은 에너지 밴드갭으로 인해 가시광 매개 광흡수와 광촉매의 가능성을 가지고 있다. 그러나 가시광선 조사에 의한 광촉매 기반 항균 활성은 아직 불분명하다. 본 연구의 목적은 Ni-Ti-O 나노튜브의 광촉매 기반의 광 특성을 분석하고 항균 활성을 평가하는 것이다. Ni-Ti-O 나노튜브를 FE-SEM으로 관찰한 결과, 길이 600 ± 80 ㎚, 외경 52 ± 5 ㎚의 깨끗하고 균질한 나노튜브가 형성되었다. Ni-Ti-O 나노튜브의 확산반사 분석결과, 450 nm에 해당되는 광촉매 밴드갭을 나타내어 가시광선 범위에서의 광촉매 효과를 발현하는 것을 확인하였다. 그리고 Streptococcus sanguinis를 이용한 CFU 항균 실험 및SOD 효소 활성 실험은 470 nm 가시광선 조사 하에서의 Ni-Ti-O 나노튜브 실험군이 다른 실험군들에 비하여 통계적으로 유의차 있게 항균능을 나타내었다(P<0.05). 따라서, Ni-Ti-O 나노튜브와 가시광 기반 광기능화의 결합은 치과분야에서 NiTi 임플란트 소재의 항균능을 향상시킬 것으로 기대된다.

다국어 초록 (Multilingual Abstract)

Ni-Ti-O nanotubes have the potential for visible light-mediated light absorption and photocatalysis due to their low energy band gap. However, their photocatalytic-based antibacterial activity under visible light irradiation is still unclear. This study aims to analyze the photocatalytic-based optical properties of Ni-Ti-O nanotubes and evaluate their antibacterial activity. From the FE-SEM observations of the Ni-Ti-O nanotubes, clean and homogeneous nanotubes with a length of 600 ± 80 ㎚ and an outer diameter of 52 ± 5 ㎚ were observed. The diffuse reflection analysis of the Ni-Ti-O nanotubes showed a photocatalytic bandgap, which is equivalent to the wavenumber of 450 nm, indicating that they exhibit photocatalytic effects in the visible light range. The CFU antibacterial test and SOD enzyme activity test using Streptococcus sanguinis showed that the Ni-Ti-O nanotube experimental group under 470 nm visible light irradiation exhibited statistically significant antibacterial activity compared to other experimental groups (P<0.05). Therefore, the combination of Ni-Ti-O nanotubes and visible light-based photofunctionalization is expected to improve the antibacterial ability of NiTi implant materials in the dental field.

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