Lactate, Pyruvate, and Excess Lactate during Ether and Halothane Anesthesia = Ether 및 Helothane 麻醉下에서의 血中 Lactate, Pyruvate, Excess Lactate 値에 對하여

국문 초록 (Abstract)

Ether 및 halothane 麻醉의 靜脈血中의 lactate와 pyruvate를 酵素的인 方法으로 測定하고 excess lactate를 算出하였다.
Ether麻醉下에서 血中 lactate는 麻醉 30分부터, pyruvate는 60分부터 有意한 增加를 보였으며, excess lactate는 30分부터 算出되어 若干 增加하는 추세를 보였다.
Halothane麻醉時에는 血中 lactate는 麻醉 120分에만 有意한 增加를 보였고, pyruvate는 意義있는 變動을 볼 수 없었으며, excess lactate는 麻醉 120分에 算出되었을 뿐이다.
本 實驗에서 ether 麻醉時의 靜脈血中의 lactate, pyruvate 및 excess lactate와 다른 硏究者들이 報告한 動脈血中의 것을 比較한 結果 lactate와 pyruvate의 絶對値만 높을 뿐 麻醉時間에 따른 變動狀이나 excess lactate値에서는 큰 差를 볼 수 없었다.
따라서 靜脈血中의 lactate, pyruvate 및 excess lactate値로 tissue hypoxia를 推定하더라도 動脈에서의 結果와 큰 差가 없으리라 示唆하였다.

다국어 초록 (Multilingual Abstract)

Lactate, pyruvate and excess lactate in venous blood have been measured by employing the enzymatic method and calculated in 24 patients, over a period of two hours during the course of general anesthesia.
When diethyl ether was used as an anesthetic, lactate and pyruvate levels showed a significantly gradual increase from 30 minutes and 60 minutes after the induction of anesthesia, respectively. And excess lactate appeared from 30 minutes after induction with following elevated value thereafter.
When halothane was used, lactate level was elevated considerably only after 120 minutes but no significant change of both pyruvate and excess lactate was observed.
In comparison to the results reported by others which obtained by using arterial blood under ether anesthesia, no considerable difference can be found both in the change of lactate and pyruvate during the course of anesthesia and in excess lactate calculated, except the fact that the absolute levels of lactate and pyruvate found in this study were somewhat higher.
From the above results, we discussed that the venous blood can be sustituted the arterial blood for the determination of lactate, pyruvate and excess lactate for evaluating tissue hypoxia during the general anesthesia.