KCI등재후보
SCIE
SCOPUS
Adipose-Derived Mesenchymal Stem Cells and Their Derived Epidermal Progenitor Cells Conditioned Media Ameliorate Skin Aging in Rats
저자
Badr Omar I. (Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt) ; Anter Aya (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Magdy Ihab (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Chukueggu Marvellous (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Khorshid Moamen (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Darwish Mohamed (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Farrag Mohamed (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Elsayed Menna (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Amr Youmna (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Amgad Yomna (Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt) ; Mahmoud Tasnim (Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt) ; Kamal Mohamed M. (Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt)
발행기관
한국조직공학과 재생의학회(Korean Tissue Engineering & Regenerative Medicine Society)
학술지명
권호사항
발행연도
2024
작성언어
English
주제어
등재정보
KCI등재후보,SCIE,SCOPUS
자료형태
학술저널
수록면
915-927(13쪽)
DOI식별코드
제공처
BACKGROUND: Skin alterations are among the most prominent signs of aging, and they arise from both intrinsic and extrinsic factors that interact and mutually influence one another. The use of d-galactose as an aging model in animals has been widely employed in anti-aging research. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) are particularly promising for skin anti-aging therapy due to their capacity for effective re-epithelization and secretion of various growth factors essential for skin regeneration. Accordingly, we aimed to examine the potential utility of Ad-MSCs as a therapy for skin anti-aging.
METHODS: In this study, we isolated and characterized adipose-derived mesenchymal stem cells (Ad-MSCs) from the epididymal fat of male Sprague Dawley rats. We assessed the in vitro differentiation of Ad-MSCs into epidermal progenitor cells (EPCs) using ascorbic acid and hydrocoritsone. Additionally, we induced skin aging in female Sprague Dawley rats via daily intradermal injection of d-galactose over a period of 8 weeks. Then we evaluated the therapeutic potential of intradermal transplantation of Ad-MSCs and conditioned media (CM) derived from differentiated EPCs in the d-galactose-induced aging rats. Morphological assessments, antioxidant assays, and histopathological examinations were performed to investigate the effects of the treatments.
RESULTS: Our findings revealed the significant capability of Ad-MSCs to differentiate into EPCs. Notably, compared to the group that received CM treatment, the Ad-MSCs-treated group exhibited a marked improvement in morphological appearance, antioxidant levels and histological features.
CONCLUSIONS: These results underscore the effectiveness of Ad-MSCs in restoring skin aging as a potential therapy for skin aging.
BACKGROUND: Skin alterations are among the most prominent signs of aging, and they arise from both intrinsic and extrinsic factors that interact and mutually influence one another. The use of d-galactose as an aging model in animals has been widely employed in anti-aging research. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) are particularly promising for skin anti-aging therapy due to their capacity for effective re-epithelization and secretion of various growth factors essential for skin regeneration. Accordingly, we aimed to examine the potential utility of Ad-MSCs as a therapy for skin anti-aging.
METHODS: In this study, we isolated and characterized adipose-derived mesenchymal stem cells (Ad-MSCs) from the epididymal fat of male Sprague Dawley rats. We assessed the in vitro differentiation of Ad-MSCs into epidermal progenitor cells (EPCs) using ascorbic acid and hydrocoritsone. Additionally, we induced skin aging in female Sprague Dawley rats via daily intradermal injection of d-galactose over a period of 8 weeks. Then we evaluated the therapeutic potential of intradermal transplantation of Ad-MSCs and conditioned media (CM) derived from differentiated EPCs in the d-galactose-induced aging rats. Morphological assessments, antioxidant assays, and histopathological examinations were performed to investigate the effects of the treatments.
RESULTS: Our findings revealed the significant capability of Ad-MSCs to differentiate into EPCs. Notably, compared to the group that received CM treatment, the Ad-MSCs-treated group exhibited a marked improvement in morphological appearance, antioxidant levels and histological features.
CONCLUSIONS: These results underscore the effectiveness of Ad-MSCs in restoring skin aging as a potential therapy for skin aging.
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