관상동맥 석회화와 경동맥 경화반을 동반한 건강검진 수검자의 위험인자 분석 = Analysis of Risk Factors in Health Examination Patient with Coronay artery Calcification and Carotid Arteriosclerosis

국문 초록 (Abstract)

심, 뇌혈관 질환의 조기 발견과 예방을 위한 검사로 다중 절편 컴퓨터 단층촬영을 이용한 관상동맥 석회화 수치와 경동맥 초음파가 널리 이용되고 있다. 본 연구는 심, 뇌혈관계 질환의 조기 진단을 위한 기초 자료를 마련하고자 관상동맥 석회화 수치와 경동맥 초음파 검사상 보이는 죽상동맥경화증과 위험인자와의 관련성에 대해 알아보았다. 2023년 1월 부터 2024년 8월까지 광주광역시 소재 C의원의 건강검진센터를 방문한 총 321명의 수검자의 검사 기록을 후향적 분석 하였고, 연령과 성별, 혈압, 체질량 지수, 총 콜레스테롤, 고밀도 지단백질(HDL)콜레스테롤, 트리글리세라이드, 저밀도 지단백질(LDL)콜레스테롤, 혈청 크레아티닌, 신사구체여과율, 당화혈색소, 공복혈당, 흡연 유무와 같은 위험 인자들의 결과와 관상동맥 석회화 수치, 경동맥 초음파 검사 결과를 이용하였다. 연구 결과, 관상동맥 석회화와 경동맥 경화반은 r=0.409의 상관관계를 보였다(p<0.001). 관상동맥 석회화와 경동맥 죽상경화반이 둘 다 있는 그룹은 둘 다 없는 그룹에 비해 평균 나이가 높고 당화혈색소와 공복혈당의 수치가 높은 것으로 나타났으며, 위험인자와의 다중 로지스틱 회귀분석 결과 당화혈색소 수치가 비정상일 경우 관상동맥 석회화와 경동맥 경화반이 동시에 나타날 확률(오즈비)이 약 2.754배 증가하는것으로 나타났다(p=0.002). 따라서, 나이와 공복혈당, 당화혈색소가 죽상동맥경화증에 유의미한 영향을 끼치는 위험인자로 보았고 이를 활용하면 심,뇌혈관 질환의 조기 발견과 예방에 도움이 될것으로 사료된다.

다국어 초록 (Multilingual Abstract)

Coronary artery calcification scores using multi-detector computed tomography and carotid ultrasound are widely used as tests for the early detection and prevention of cardiovascular diseases. This study examined the relationship between coronary artery calcification scores and ateriosclerosis and risk factors seen in carotid ultrasound examinations to provide basic data for the early diagnosis of cardiovascular diseases. A total of 321 examinees who visited the Health Screening Center of C Hospital in Gwangju City from January 2023 to August 2024 were retrospectively analyzed, and the results of risk factors such as age, sex, blood pressure, body mass index, total cholesterol, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, serum creatinine, glomerular filtration rate, glycated hemoglobin, fasting blood sugar, and smoking status, as well as coronary artery calcification scores and carotid ultrasound examination results, were used. As a result of the study, coronary artery calcification and carotid artery sclerotic plaques showed a correlation of r=0.409(p<0.001). The group with both coronary artery calcification and carotid artery atherosclerotic plaque was found to have a higher average age and higher levels of glycated hemoglobin and fasting blood sugar compared to the group without both, and as a result of multiple logistic regression analysis with risk factors, glycated hemoglobin levels If is abnormal, the odds ratio of coronary artery calcification and carotid artery sclerosis appearing simultaneously increases by about 2.754 times (p=0.002). Therefore, age, fasting blood sugar, and glycated hemoglobin are considered risk factors that have a significant impact on arteriosclerosis, and their use is expected to be helpful in early detection and prevention of cardiovascular and cerebrovascular diseases.

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