복분자로부터 분리동정한 Lactobacillus plantarum GBL16, 17균주를 포함한 시제품의 장내 미생물 변화 = Change of Intestinal Microbial in Prototype Including Lactobacillus Plantarum GBL16 and 17 Strains Isolated from Black Raspberry

다국어 초록 (Multilingual Abstract)

This study was performed to probiotic including Lactobacillus plantarum stains (GBL16 and 17) isolated from black raspberry identified intestinal microbial changes. The experiment was control (CTL), Probiotic Milk Candy (L. plantarum GBL16 and 17 combination group; PMC) and Bebe Finger Yogurt (BFY) were provided to Balb/c mice for 8 weeks. The number of intestinal lactic acid bacteria was significantly increased in PMC. There was not changed in the total number of bacteria in each group, PMC and BFY showed various changes the abundance of genus Lachnospiraceae, Alistipes. Our finding expected that the modulation of gut microbiota by probiotic was related with the beneficial effects, but further application study to human is necessary.

국문 초록 (Abstract)

이 연구는 복분자에서 분리된 Lactobacillus plantarum stain (GBL16 및 17)을 포함한 probiotic에 대해 수행되었으며, 장내 미생물 변화를확인하였다. Balb/c 마우스모델에서 GBL 16, 17을 포함한 시제품인 PMC와 시판중인 유산균 과자 BFY를 8주간 경구 투여 하였다. PMC의투여는 장내 미생물총의 균형을 향상시키고, 장내개선에 긍정적인 영향을 보였다. 맹장을 이용한 NGS 분석을 통해 확인한 결과, 스트레스 후증가하는 양상을 보이는 균인 Lachnospiraceae균이 감소하는 경향을 보였다. Alistipes균의 증가는 염증성 장 질환에 효과가 있을 것으로 판단되나, 추후 더 많은 연구가 필요할 것으로 보인다.

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