지방수준을 달리한 식이에 카페인의 첨가가 흰쥐의 체내지방대사에 미치는 영향 = Effect of Caffeine on Lipid Metabolism in the rats Fed with different Levels of Dietary Lipids

다국어 초록 (Multilingual Abstract)

This study was performed to investigate effect of caffeine intake on lipid metabolism in rats with standard diet (SD) and high-fat diet (HF) during 4 weeks after weanling. Thirty male rats of Spague-Dawley strain, weighing 73.6±0.2g were blocked into 6groups and were fed diets containing pure caffeine or not.
Serum cholesterol level was significantly higher in non-caffeine standard diet group than that in non-caffeine high fat diet group. Addition of caffeine to HF showed increasing effect of serum cholesterol. Within SDgroup the content of liver cholesterol in caffeine-fed animals was much more than that in control group.
Serum triglyceride level was decreased when caffeine was added to SD. But this effect was not observed in HF.
Serum total lipid level of high caffeine-fed rats was significantly higher than that of control group in both SD and HF group. Only in HF, the content of liver total lipid in high-caffeine group was much less than that in non-caffeine group.
Only in SD group, microscopic observation of hepatocyte at the level of nucleus
showed somewhat more blurring at the nucleus area of high-caffeine group than that of non-caffeine group. There was any histologic effect of caffeine in intestinal cells.
This results show that homeostatic mechanism of lipid metabolism in highfat-caffeine group is less effectively regulated than in standard diet-caffeine group.
From this standpoint, we suggest that too much drinking of caffeine-containing
beverage and concurrently high intake of fatty food is undesirable.