족부백선에서 Terbinafine 1% 1주와 Clotrimazole 1% 4주 국소도포 치료에 대한 이중맹검 비교 연구 = A Comparison of Terbinafine 1% Cream Given for 1 Week With Clotrimazole 1% Cream Given for 4 Weeks in Treating Tinea Pedis

다국어 초록 (Multilingual Abstract)

Tinea pedis is the most common and chronic dermatophyte infection. Clotrimazole 1% cream is well known antifungal agent and to be applied generally for 4 weeks at the treatment of tinea pedis. Terbinafine is a newly developed antifungal agent with a fungicidal action. The short-term treatment of tinea pedis by terbinafine has veen suggested as an effective topical treatment. We tried to compare the efficacy of terbinafien 1% cream and clotrimazole 1% cream for tinea pedis in double-blind, parallel fashion.
The 113 patients with tinea pedis diagnosed by clinical feature and mycological findings including KOH mount and fungus culture, were enrolled in this study. Terbinafine 1% cream applied twice daily for 1 week and inert cream for the next 5 weeks. Clotrimazole 1% cream applied twice daily for 4 weeks and inert cream for next 2 weeks. Mycologic characteristics and clinical symptoms and sings were assessed at baseline, at the end of 1, 2, 4 and 6 weeks. Total one hundred patients consisted of 50 for terbinafine and 50 for clotrimazole were finally evaluated, and paralleled in age, sex and total clinical scores of the baselines.
The total reduced percent of clinical signs and symptoms from baseline were 72% at week four and 81% at week six in terbinafine, and 61% and 66% respectively in clotrimazole(P<0.05). The percent of negative mycology at week two, were 92% in terbinafine and 78% in clotrimazole(p<0.05), however no significant difference in the other week six, were 30%(p<0.05) for very good and 46% for good in terbinafine, and 14% respectively in clotrimazole.
These result indicated that a one week treatment of terbinafine 1% cream may be more effective than a four week treatment of clotrimazole 1% cream for tinea pedis.