갑상선 기능항진증을 동반한 임산부와 그 신생아에 관한 연구 = Study on the Pregnant Women with Hyperthyrodism and Their Newborns

다국어 초록 (Multilingual Abstract)

This study was to evaluate 47 pregnant women with hyperthyrodism (39 treated hyperthroid pregnant group and 8 neglected hyperthyroid pregnant group ) and compare the maternal and fetal outcomes between these two groups at the Dept. of Obstetrics and Gynecology of Ewha Woman`s University Hospital during the period 8 years from Jan., 1985 to Dec., 1992. Student`s t.test and x2 test were used for statistical comparisons. The results were as folows : 1. The incidence of pregnant women with hyperthyrodism was 0.28% of all deliveries. Durations since the diagnosis of hyperthyrodism was confirmed initailly were less than 1 year (19.2%) 2 year (17.0%), 3 year (14.9%) and 3 or more year (48.9%). 2. Pregnant women with hyperthyrodism had the histories of spontaneous abortion and premature delivery. These findings of the treated hyperthyroid group were not significantly different from those of neglected hyperthyroid group . 3. Prematrue deliveries and babies with birth weight less than 2.5kg in the treated hyperthyroid group were significantly more decreased than those in the neglected hyperthyroid group . 4. T3 and T4 levels in the treated hyperthyroid group were not significantly difference from those in the neglected hyperthyroid group, but TSH levels was significantly higher in the treated hyperthyroid group than in the neglected hyperthyroid group, and the same findings in the babies (not different in the T3 and T4 levels, but significantly difference in TSH level). 5. The majorities (82.1%) of the treated hyperthyroid group were managed by (PTU) 100-400mg, the other (12.8%) by PTU and propranolol, and the rest (5.1%) by PTU after operation . Half of the neglected hyperthyroid group (50.0%) had stopped medication themselves since they predicted pregnancy, 37.5% of this group had stopped medication after several month`s medication before this pregnancy and the rest (12.5%) had stopped medication because of headache. Still hyperthyroid state after management in the treated hyperthyroid group was significantly lower than that in the neglected hyperthyroid group . 6. Maternal complications were premature labor(treated group : 10.3%, neglected group 50.0%), preeclampsia, antepatum anemia, prematrue rupture of membrane , placenta previa and gestational diabetes mellitus. Fetal complications were low birth weight babies (treated group : 15.4%, neglected group : 50.0%) fetal growth retardation low Apgar score, hyaline membrane disease, postmaturity and stillbirth. Newborns with transient congential hyperthyrodism born of mothers with the treated hyperthyroid group were not significantly increased than those born of mothers with the neglected hyperthyroid group.