모체의 혈중 단백 및 스테로이드 호르몬 측정을 이용한 절박유산의 예후 판정 = Prediction and Monitoring of the Pregnosis of Threatened Abortion by Biochemical and Hormonal Analysis of Maternal Serum

다국어 초록 (Multilingual Abstract)

For the purpose of evaluating the prognosis of the patients of threatened abortion the 24 hour-urinary titer if human chorionic gonadotropin, serum levels of placeful lactogen, prolactin, alpha-fetopretein, estradiol-17b, total estriol, progesterone, testosteronr and cortisol in 862 urine and serum samples from 241 cases of narmal pregnancy and 82 cases of threatemed abortion were measures weelky from 5th to 20th gestational weeks. Thw group of threatened abortion was again divided into 2 subgroups, that of 38 cases of favorable outcome in which the cases progress to narmal pregnancy up to at least 28th gestational weeks and that of 44 cases poor pregbosis in which the cases terminated in abortion within 28th gestational weeks. Thw changing patterns of all the data of 3 groups according to their gestational weeks were compared with each other. And considering certain data above the value of Mean minus I.S.D. of control group as normal and those below that value as subnormal all the data were compared with their own prognosis. Thw result were as follows. 1) In the subgroup of favorable outcome of threatened abortion, the levels of all 9 parameters of urinary hCG, serum hPL, hPRL, AFP, estradiol-17b, total estriol, progesterone, testosterone andcortisol were considerably lower than those of control group in geneal but were not significant statistically. 2) In the subgroup of abortion all those of 9 parameters were signifiantly lower than those of control group but those of only 4 parameters of urinary hCG, serum hPL, hPRL and estradiol-17b were significantly lower than those of both the control group and the subgroup of favourable putcome in general. 3) The accuracy rates to predic: the prognosis of threatened abortion with each of most rliable 4 hormonal parameters- urinary hCG, serum gPL, hPRL and estradiol-17b - were 76.8, 80.9, 86.1 and 83.7% respectively. 4) The overall accuracy rates to predict favorable outcome with any 2, 3 and all 4 normal rnages among most reliable above 4 hormaonal parameters were 92.7, 97.7 and 100.0% respectively. 5) The overall accuracy rates to predict abortion with any 2, 3, all 4 subnormal ranges among most reliable above 4 hormonal parameters were 93.9, 99.1 and 100.0% respectively. 6) Considering the results mentioned above, measurement of 4 parameters of urinary hCG, serum hPL, hPRL and estadiol-17b evaluating at least 3 ones simultaneously can be preferred in evaluating and predicting the prognosis of threatened abortion.