Bilirubin의 造血促進效果 = Erythropoietic Effect of Bilirubin

국문 초록 (Abstract)

著者는 bilirubin의 量에 따르는 造血促進作用의 變動을 檢討하기 위하여 흰 숫쥐에 體重 100g當 bilirubin 溶液을 每日 1.0㎎, 5.0㎎ 및 10.0㎎ 筋肉內로 各各 2日間 注射하고 實驗 第 5日에 網赤血球數, 骨髓有核赤血球數 및 赤血球 ^59Fe利用率을 測定하였으며 아울러 失血性貧血에 對한 bilirubin의 造血促進效果에 對해서도 檢討하여 다음과 같은 結果를 얻었다.
(1) 蒸溜水 및 溶劑를 注射한 對照群에서는 注射前後에 있어서 網赤血球數의 變動은 없었으며 蒸溜水 注射群과 溶劑 注射群 사이에 있어서도 骨髓有核赤血球數 및 赤血球 ^59Fe利用率에 差가 없었다.
(2) 體重 100g當 1.0㎎, 5.0㎎ 및 10.0㎎의 bilirubin注射群에서는 bilirubin注射量이 커짐에 따라 注射前後의 網赤血球數 差가 더욱 增大하였으며 骨髓有核赤血球數 및 赤血球 ^59Fe利用率도 增加하는 傾向이 있었다.
(3) 心臟으로부터 每日 1.0㎖씩 2日間 採血하여 失血性貧血을 일으키는 同時에 bilirubin을 體重 100g當 5.0㎎을 每日 1回 2日間 注射한 實驗群에서는 失血性貧血만을 일으킨 對照群에 비하여 骨髓有核赤血球數가 有意하게 增加하였으며 赤血球 ^59Fe利用率도 增加하는 傾向이 있었다.

다국어 초록 (Multilingual Abstract)

This study was undertaken to assess the erythropoietic effect of bilirubin, with special reference to dose response relationship, as well as it's effect on acute posthemorrhagic anemia with following results.
(1) No appreciable difference in reticulocyte count was noted between preinjection and postinjecton values in rats injected distilled water and solvent respectively. Also no significant difference in both marrow nucleated red cell count and erythrocyte ^59Fe incorporation was found between the distilled water and the solvent injected groups.
(2) The difference of reticulocyte counts between the preinjection and postinjection values was widened proportionally as the doses of the bilirubin increased. Also it was noted that both the marrow nucleated red cell count and erythrocyte ^59Fe incorporation tended to rise proportionally as the doses increased.
(3) A significant increase in the marrow nucleated red cell count and erythrocyte ^59Fe incorporation was seen in acute posthemorragic anemic rats with bilirubin as compared with those without bilirubin.