ICR 마우스에서 염산/에탄올로 유발된 위궤양에 대한 현미를 주성분으로 한 혼합물의 보호효과 = Protective Effects of a Brown Rice-based Grains Blend on Hydrochloric Acid/Ethanol-induced Gastric Injury in ICR Mice

다국어 초록 (Multilingual Abstract)

Brown rice is known to have various therapeutic effects, such as anti-diabetic, anti-dyslipoproteinemia, anti-cancer, cardio-protective, and antioxidant effects, due to its diverse phytochemical compounds that benefit health. However, its anti-gastric ulcer effects have not yet been scientifically proven in animal models. To investigate the novel protective function of brown rice against gastric ulcer (Ulc), alterations in key markers for Ulc improvement in hydrochloric acid/ethanol (HCl/EtOH)-treated ICR mice with Ulc were analyzed after cereal powder from a brown rice-based grains blend (BGB) was administered to them. BGB was prepared by combining brown rice (38.6%), barley (19.2%), mung beans (32.7%), jujube (3.6%), and cabbage (2.7%) powder. In the BGB+Ulc-treated group, the damage area of the gastric mucosa and the histological index significantly decreased compared to the Vehicle+ Ulc-treated group, although the body and stomach weights remained constant. Moreover, in the BGB+Ulc-treated group, significant improvements in the transcription level of several inflammatory cytokines, including interleukin (IL)-6, IL-1β, and transforming growth factor-β, were detected in the stomach. However, the BGB treatment did not induce significant toxicity in the liver or kidney tissue. Therefore, the results of the present study suggest that BGB has the potential to be used as a functional food against Ulc without significant toxicity.