토끼 심폐소생술에서 에피네프린 단독사용과 에피네프린과 바소프레신 혼합사용시 뇌의 비재관류 현상 = Comparison of Epinephrine and Epinephrine with Vasopressin Mixture on the Cerebral "No-Reflow" in a Rabbit Medel of Cardiopulmonary Resuscitation

다국어 초록 (Multilingual Abstract)

Background: The more vital organ blood flow during cardiopulmonary resuscitation(CPR), the more successful outcome. The worldwide CPR drug of choice, epinephrine also has some limitations and is often challenged by another catecholamine drug. This study was designed to compare the effects of epinephrine with those of vasopressin and epinephrine mixture on cerebral no-reflow during closed-chest CPR in a rabbit model of ventricular fibrillation
Design: Prospective, randomized, experimental study.
Setting: University research laboratory.
Subjects: Domestic rabbits, 3 to 6 months of age
Interventions: Four rabbits were randomly allocated to receive only 0.020 mg/kg of epinephrine(group 1) and another four rabbits were received both 0.020 mg/kg of epinephrine and 0.8 U/kg of vasopressin after 5 mines of cardiac arrest(group 2).
Measurements and Main Results: Carotid arterial blood flow and arterial gas analysis were showed no ststistical difference between two groups but in the points of cerebral no reflow area and fluorescence exposure time, there were significant differences(group 1,515 ±.45%, group 2,6.38 ±.54% , p=.029/group 1; 29.65 ±17.09 seconds, group 2; 17.98 ±18.75seconds, p=.014).
Conclusions: In cardiac arrest there is some synergistic effect with epinephrine and vasopressin mixture on cerebral no-reflow phenomenon.