한국인에서 익상편과 혈청 알칼리인산가수 분해효소와의 관계 = Nationwide Cross-sectional Study of Association between Pterygium and Alkaline Phosphatase in a Population from Korea

다국어 초록 (Multilingual Abstract)

Purpose: We determined whether elevated serum alkaline phosphatase (ALP) was related to prevalence, location, type, length, and recurrence of pterygium in a population from the Republic of Korea.
Methods: A nationwide cross-sectional dataset, the Korean National Health and Nutrition Examination Survey (2008-2011), was used in this study. All participants were > 30 years of age and underwent the ALP test and ophthalmic evaluation (n = 22,359).
One-way analysis of variance, the chi-square test, and Fisher’s exact test were used to compare characteristics and outcomes among participants. Multivariable logistic regression was used to examine the possible associations between serum ALP levels and various types of pterygium. Data were adjusted for known risk factors for development of pterygium and ALP elevation (age, sex, residence, sunlight exposure, drinking, smoking, hypertension, diabetes, BMI, AST, ALT, vitamin D, and HDL).
Results: The overall prevalence of pterygium was 8.1%, and participants with pterygium had higher levels of serum ALP (p < 0.001). Participants with higher serum ALP had a significantly higher prevalence of all types of pterygium than those in the lower serum ALP quartiles. After adjusting for potential confounding factors, multivariate logistic regression analysis revealed that ALP was associated with the prevalence of pterygium (odds ratio [OR], 1.001; p = 0.038). Trend analysis between the OR and ALP quartiles revealed a linear trend in overall prevalence and in the intermediate type of pterygium. Subgroup analysis revealed a stronger correlation in participants > 50 years of age. One-way analysis of variance revealed an association between the size of pterygium and serum ALP quartile levels. Serum ALP was not associated with recurrence of pterygium.
Conclusions: Increased serum ALP was associated with the prevalence and size of pterygium.

국문 초록 (Abstract)

목적: 본 연구에서는 증가된 혈청 알칼리인산가수 분해효소(alkaline phosphatase, ALP)가 한국인 집단의 유병률, 위치, 종류, 길이, 재발 유무와 관련이 있는지를 조사하였다.
대상과 방법: 본 연구는 2008년부터 2011년에 시행한 한국 국립건강영양조사의 자료를 이용하였다. 알칼리인산가수 분해효소와 안과검사를 동시에 시행한 30세 이상의 환자(n=22,359)를 대상으로 하였다. 단방향 분석, 카이 제곱 검정 및 피셔 정확한 검정을 사용하여 참가자의 특성과 결과를 비교하였다. 다변수 로지스틱 회귀 분석을 통해 혈청 ALP 수준과 다양한 유형의 익상편의 연관성을 조사하였다. 익상편 및 알칼리인산가수 분해효소 상승 발달에 대한 알려진 위험 인자(연령, 성별, 거주지, 햇빛 노출, 음주, 흡연, 고혈압, 당뇨병, 신체질량지수, 간 수치, 비타민 D 및 고밀도지단백질) 등을 보정하였다.
결과: 익상편의 유병률은 8.1%였고, 혈청 알칼리인산가수 분해효소는 익상편이 있는 환자에서 높았다(p<0.001). 잠재적 교란 인자를 보정한 후, 다변량 로지스틱 회귀 분석 결과 혈청 알칼리인산가수 분해효소는 익상편 유병률과 관련이 있었다(odds ratio [OR], 1.001; p=0.038). OR와 혈청 알칼리인산가수 분해효소와의 경향 분석은 전반적인 유병률과 익상편의 중간 유형에서 선형 경향을 보였다. 혈청 ALP는 익상편 재발과의 관련성을 보이지 않았다.
결론: 혈청 알칼리인산가수 분해효소의 증가는 익상편의 유병률과 크기와 연관성을 보였다.

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