고단백 저칼로리 균형식에 의한 체중 및 건강위험 감소 효과 연구 = A Study of Effect of Low Calorie High Protein Diet on Weight & Health Risk Reduction

다국어 초록 (Multilingual Abstract)

It is well known that obesity is significantly associated with cbronic diseases such as cardiovas- cular disease, hypertension, and diebetes. However, a existing methods to reduce the level of obesity is not simple and premature. Diet, exercise, and use of weight reducing drugs are widely used as the methods of weight loss, but these methods are frequently coexist with the side effects or regain of weight. Therefare, this study under went to evaluated the high protem-low calorie dietary food(Balance) as another method of weight loss. Specifically, we evaluated change of weight, body mass index, waist-hip ratio, body fat content, the lipid profiles, kidney function, liver function, thyroid, change of sex hormone, and glucose rnetabolism.
A total of 61 women were recruited from Ajou university comprehensive health center and Ajou university medical complex(ie, hospital and medical school). Subjects with any type of metabolic diseases such as, chronic diseases, cardiovascular disease, diabetes, liver diseases and cancer were excluded frorn the study. Beginning of the study, participants diet, family history, and history of weight change were evaluated by the trained interviewer. We asked the participants to wear light clothing during the weight and hetght rneasurement. Fasting, more than 8 hours, blood was drawn to evaluate any metabolic indices.
Study participants mean age was 35.6 years old(youngest was 18 years and oldest 57years oid). Approximately 70% of the participants have had their obesity and other risk factors rneasured more tkan a two occasions. No sigmficant effects of Balance on most of the study variables were observed during the follow-up period of 7 to 145 days. However, we observed significant difference on total cholesterol, lmdy fat and fasting glucose level after Balance use. The mean weight was changed approximately 5%(p$lt;0.001), 73.4kg to 69.9kg, during 66 days of the treatment. Furthermore, we observed subjects with 2kg weight gain to maximum of 14,2kg reduction. Although, it is not statistically significant, we observed the mean of 3cm reduction in waist-hip ratio. On the other hand, the BMI was significantly(p0.001) reduced from 29.3 to 27.9. We further analyzed the effects of Balance among the three age groups($lt;30yrs, 30-39yrs, and $gt; 40yrs). We found similar pattern and magnitude of weight change among the three groups. However, the pattem was somewhat different in waist-hip ratio, In older group($gt;40yrs), waist-hip ratio declined in the begirming of thc treatment but returned to the initial level. However, in the other two groups($lt;30yrs, and 30-39yrs), waist-hip ratio declined persistently from the beginning of the treetment. Although, weight and BMI was inversely correlated with participants age but it was not significantly affecting on change of either weight or BMI.
In conclusion, we observed a positive effeet of high protein low calorie diet food on the reduction of weight, body fat, total cholestero! And glueose. Howevet, one should be cautious with the high protein diet which subsequently increase in formation of ketone body and possibly results in dehydraiion. And low caloric diet also reduce in energy expenditure, thus to prevent this phenomenon we suggest that low caloric diet should be combined with an exercise to maximize and maintain weight loss.