골관절염 유발이 흰쥐의 에너지소비량 및 에너지 기질 이용에 미치는 영향 = Effects of Osteoarthritis Induction on Energy Expenditure and Energy Substrate Utilization in White Rats

국문 초록 (Abstract)

본 연구의 목적은 골관절염 유발이 흰쥐의 에너지소비량과 에너지기질이용에 미치는 영향을 확인하고자 실시하였다.
흰쥐의 무릎 관절강 내에 Monosodium iodoacetate(MIA)를 주입하여 2주 동안 관절염을 유발시켰고, 이후 족적평가와 더불어 대사챔버에 넣어 에너지소비량과 에너지 기질 이용을 평가했다. 본 연구의 결과 첫째, 골관절염 모델은족적평가 시 통증 및 보행 문제로 대조군에 비해 족적 강도가 낮은 것으로 나타났다(p<.001). 둘째, 골관절염 모델은대조군에 비해 산소섭취량과 에너지소비량이 더 낮은 것으로 나타났다(p<.01, p<.05). 셋째, 골관절염 모델은 대조군에 비해 탄수화물 산화량이 높았으며 지방 산화량의 경우 더 낮은 것으로 나타났다(p<.05, p<.01). 결론적으로 골관절염 유발은 전체적인 활동량을 줄어들게 하여 총에너지 소비량을 감소를 가져오는 것으로 나타났으며, 이 때 사용되는에너지원은 주로 탄수화물로써 세포의 복구와 생산 메커니즘인 것으로 사료된다. 향후 골관절염 모델에서 혈액분석및 에너지대사에 관여하는 유전자의 생화학분석을 통해 골관절염 시 에너지섭취와 소비에 대한 추가적 연구가 필요할것으로 판단된다.

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the effect on energy expenditure and energy substrate utilization for 24 hours in an osteoarthritis model. In the MIA group, arthritis was induced for 2 weeks by injecting MIA into the joint cavity of the knee, followed by foot print evaluation. In addition, energy expenditure and energy substrate utilization were measured for 24 hours in metabolic chamber. As a result of this study, first, the osteoarthritis model showed lower footprint intensity than the control group due to pain and gait problems during foot evaluation (p<.001). Second, the osteoarthritis model showed lower oxygen uptake and energy expenditure than the control group (p<.01, p<.05). Third, the osteoarthritis model showed higher carbohydrate oxidation and lower fat oxidation compared to the control group (p<.05, p<.01). In conclusion, it was shown that osteoarthritis induction reduces overall activity and thus reduces total energy expenditure, and the energy substrate used at this time is mainly carbohydrate, which is thought to be the result of the cell's recovery and production mechanism.

참고문헌 (Reference)

• 1 Daste, C., "physical activity for osteoarthritis:Efficiency and review of recommandations" 88 (88): 105207-, 2021
• 2 Item-Glatthorn, J. F., "Validity of the intelligent device for energy expenditure and activity accelerometry system for quantitative gait analysis in patients with hip osteoarthritis" 93 (93): 2090-2093, 2012
• 3 Mobasheri, A., "The role of metabolism in the pathogenesis of osteoarthritis" 13 (13): 302-311, 2017
• 4 Sahin, E., "The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats" 13 (13): 6499-, 2023
• 5 "The Korean Health Insurance Review & Assessment Service"
• 6 유충성 ; 김지수 ; 견성환 ; Takeshi Hashimoto ; Hironori Tomi ; 임기원, "Synergic effect of exogenous lactate and caffeine on fat oxidation and hepatic glycogen concentration in resting rats" 한국운동영양학회 26 (26): 5-13, 2022
• 7 de Rooij, M., "Prognosis of Pain and Physical Functioning in Patients With Knee Osteoarthritis : A Systematic Review and Meta-Analysis" 68 (68): 481-492, 2016
• 8 Wang, T, "Pro-inflammatory cytokines: The link between obesity and osteoarthritis" 44 : 38-50, 2018
• 9 Long H, "Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019" 74 (74): 1172-1183, 2022
• 10 Henchoz, Y., "Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls" 51 (51): 1500-1507, 2012
• 11 Ashford, S, "Osteoarthritis:A review" 39 (39): 1-8, 2014
• 12 Bonnet, C. S., "Osteoarthritis, angiogenesis and inflammation" 44 (44): 7-16, 2005
• 13 정나나 ; 박미영 ; 김지수 ; 박훈영 ; 황혜정 ; 이치호 ; 한진수 ; 소재무 ; 박종훈 ; 임기원, "Non-exercise activity thermogenesis (NEAT): a component of total daily energy expenditure" 한국운동영양학회 22 (22): 23-30, 2018
• 14 Korean National Health Insurance Service, "National Health Insurance Statistical Yearbook 2020" 2019
• 15 Choi, T. Y., "Moxibustion for the treatment of osteoarthritis: An updated systematic review and meta-analysis" 100 : 33-48, 2017
• 16 Stevenson GW, "Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats : implications for preclinical behavioral assessment of chronic pain" 98 (98): 35-42, 2011
• 17 Preiser, J. C., "Metabolic response to the stress of critical illness" 113 (113): 945-954, 2014
• 18 Mahajan, A., "Menopause and Osteoarthritis : Any Association" 9 (9): 171-172, 2018
• 19 GBD 2021 Osteoarthritis Collaborators, "Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021" 9 : e508-e522, 2021
• 20 권인수, "Endurance exercise training reinforces muscular strength with improvements in mitochondrial oxidative capacity, lysosome reformation, and myogenic differentiation against doxorubicin-induced skeletal muscle wasting in mice" 한국운동영양학회 27 (27): 76-86, 2023
• 21 Taruc-Uy, R. L., "Diagnosis and treatment of osteoarthritis" 40 (40): 821-, 2013
• 22 Katz, J. N., "Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review" 325 (325): 568-578, 2021
• 23 Mills, K., "Biomechanical deviations during level walking associated with knee osteoarthritis:a systematic review and meta-analysis" 65 (65): 1643-1665, 2013
• 24 Sacitharan P. K., "Ageing and Osteoarthritis" 91 : 123-159, 2019
• 25 Abdel Jaleel G. A., ". Impact of type III collagen on monosodium iodoacetate-induced osteoarthritis in rats" 6 (6): e04083-, 2020