임상 : 비비 양성 수막종의 노발리스 방사선 수술 및 정위적 분할 방사선 치료 -임상분석- = Novalis Radiosurgery and Fractionated Stereotactic Radiotherapy for Non-Benign Meningiomas -Clinical Analysis-

다국어 초록 (Multilingual Abstract)

Objective: Atypical and malignant meningiomas (AM, MM) are known to be rare and show aggressive behavior. Limit-ed data are available concerning the clinical features, and role of radiosurgery with non-benign meningiomas. The objec-tive of this study is to assess the local control rate, the risk of complications, and the variables that predict outcome in non-benign meningioma patients treated with radiosurgery with Novalis system. Methods: Between 2000 and 2009, 20 lesions of 10 patients were treated with radiosurgery using Novalis system for non-benign meningiomas (9cases AM, 1case MM) at our institution. FSRT were used in eloquent area and large size, pa-ranasal sinus, in close proximity to the optic nerve, prior irradiated sites. The changes of tumor size, volume , and KPS after RS were examined retrospectively during mean follow up period of 5 years. Mean target volume was 30,280.37 mm3. Mean total dose was 21.72 Gy in SRS and 39.88 Gy with 2.27 Gy per fraction in FSRS. Results: During follow-up period, all patients were survived and complications associated with RS were not observed. Mean target volume was 30,280.37 mm3. Mean total dose was 21.72 Gy in SRS and 39.88 Gy with 2.27 Gy per fraction in FSRS. Overall local tumor control rate was 95%. 11 lesions were decresed in size. 8 lesions were no change, 1 lesion was increased. Conclusions: These data demonstrate that radiosurgery using Novlais system is an effective and safe treatment modality for non-benign meningiomas with a minimal risk. We think that follow-up for longer periods is needed to assess exact ef-fectiveness of RS for non-benign meningiomas.