여성성선과 갑상상선과의 상호관계 : 제1편, 제1보 : Estrogen 투여가 갑상선에 미치는 조직학적 변화 = Interrelationship between the female sex gland and thyroid gland Part I. Report I. Histological changes of the thyroid gland caused by the application of estrogen

다국어 초록 (Multilingual Abstract)

The interrelationship between the thyroid gland and the female sex gland is too complicated and delicate to produce a concerted opinion about it at present. There have been many clinical or experimental researches on this interrelationship, but some assert the restraint, the other acceleration, or still other no relation at all, thus giving no detailed infermation. The writer intends to report the histological changes of the thyroid gland caused by the application of estrogen for the purpose of clarifying the interrelationship and mutual functional mechanism between the estrogen and the several endocrine glands and especially various aspects of its relation with the thyroid gland. For experiment, healthy mature mice with the weight of about 20 glams were divided into the following five groups, each group consisting of five mice except for the control group consisting of ten. First group - Control group, consisting of normal mice. Second group - Small amount of estrogen (10㎍s.) was applied every day for 7 days. Third group - Large amount of estrogen (100㎍s.) was applied every day for 10 days. Fourth group - After castration, bred for 35 days, and thereafter thyroidectomy.
Fifth group - After castration, medium amount of estrogen (60㎍s.) was applied every day for 10 days.
Throughout all the five groups, tissue specimen were embedded in paraffin, and 5 μ shreds were made, and stained with hematoxilin-eosin. Results of the experiment are:- 1) In the group where small amount of estrogen (5㎍s.) was applied for 7 days, follicles increased as compared with the control. Follicles have relatively shrunk, colloid was somewhat thin, epithelial cells round or flat, with no hypertrophy of interstitial tissue and no hyperemia. 2) In the group where large amount of estrogen (100㎍s.) was applied every day for ten days, there appeared the decrease of the number of follicles and the hypertrophy of follicles, and colloid was thickly accumulated, epithelial cells flat, with a conspicuous hypertrophy of interstitial tissues and a little hyperemia. 3) In the group where 35 days had passed after castration and then thyroidectomy was done, the number of follicles decreased, follicles showed a hypertrophy or had a medium size, colloid was accumulated thickly, and epithelial cells were flat, with a little and not so conspicuous hyperplasia of interestitial tissues.
4) In the group where after castration a medium amount of estrogen(60㎍s.) was applied for 10 days, there appeared the increase of the number of follicles and the shrinkage of follicles, and colloid was relatively thin, epithelial cells flat, with no conspicuous hyperplasia of interstitial tissues and a conspicuous hyperemia.
These findings induce the following conclusions:- 1) In the groups where the amount of estrogen was small there appeared the increase of the number of follicles, the shrinkage of follcles, thin colloid, many of round epithelial cells and the hyperfunction of thyroid gland. 2) In the groups where amount of estrogen was large, there appeared the decrease of the number of follicles, the hypertrophy of follicles, the accumulation of colloid, flat epithelial cells, and hypofunction of thyroid gland. 3) 30 days after the castration, there occurred the decrease of thyroid gland, but the application of estrogen caused the activating figure of its function