핀 고정 천공형 티타늄막을 이용한 수직적 체조제증대술에 관한 연구 = Exophytic bone formation using porous titanium membrane combined with pins in rabbit calvarium.

다국어 초록 (Multilingual Abstract)

The purpose of this study was to evaluate exophytically vertical bone formation in rabbit calvaria by the concept of guided bone regeneration with a custom-made porous titanium membrane combined with bone graft materials. For this purpose, a total of 12 rabbits were used, and decorticated calvaria were created with round carbide bur to promote bleeding and blood clot formation in the wound area. Porous titanium membranes (0.5 mm in pore diameter, 10 mm in one side, 2 mm in inner height) were placed on the decorticated calvaria, fixed with metal pins and covered with full-thickness flap. Experimental group I was treated as titanium membrane only. Experimental group II, III, IV was treated as titanium membrane with BBM, titanium membrane with DFDB and titanium membrane with FDB. The animals were sacrificed at 8 and 12 weeks after surgery, and new bone formation was assessed by histomorphometric as well as statistical analysis. 1. Porous titanium membrane was biocompatable and capable of maintaining the regeneration space. 2. At 8 and 12 weeks, all groups demonstrated exophytic bone formation and there was a statistical significant difference among different groups only at 12 weeks. 3. The DFDB group revealed the most new bone formation compared to other groups (p<0.05). 4. At 12 weeks, DFDB and FDB groups showed the most significant resorption of graft materials (p<0.05). 5. The BBM was not resorbed at all until 12 weeks. 6. The fixation metal pin revealed excellent effect in peripheral sealing. On the basis of these findings, we conclude that a porous titanium membrane may be used as an augmentation membrane for guided bone regeneration, and DFDB as an effective bone forming graft material. The fixation of the membrane with pin will be helpful in GBR technique. However, further study is required to examine their efficacy in the intraoral experiments.

참고문헌 (Reference)

• 1 "탈회동결건조골과 합성골이식재가 치조골 결손부 재생과정에 미치는 영향" 24 : 671-684, 1994
• 2 "골유도재생술시 그물형 티타늄막의 천공수가 골형성에 미치는 영향" 34 : 411-424, 2004
• 3 "Vertical ridge augmentation using xenogenic material supported by a conFigureured titanium mesh Clinicohistopathologic and histochemical study" 18 : 440-446, 2003
• 4 "Titanium mesh and particulate cancellous bone and marrow grafts to augment the maxillary alveolar ridge" 15 : 263-268, 1986
• 5 "The use of titanium mesh in conjuncion with autogenous bone graft and inorganic bone mineral bio Oss for localized alveolar ridge augmentation a human study" 23 : 185-195, 2003
• 6 "The use of e-PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets:A prospective multicenter study" 9 : 31-40, 1994
• 7 "The storage of marrow and its relation to periodontal grafting procedures" 46 : 162-170, 1975
• 8 "The significance of angiogenesis in guided bone regeneration" 8 : 244-288, 1997
• 9 "The role of distraction osteogenesis in oral and maxillofacial surgery" 56 : 805-806, 1998
• 10 "The influence of cortical peripheral blood on the kinetics of guided bone regeneration" 10 : 85-94, 1999
• 11 "The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants" 9 : 151-162, 1998
• 12 "The combined use of bioresorbable membranes and xenografts or autografts in the treatment of bone defects around implants" 9 : 487-498, 1999
• 13 "The biological effect of natural bone mineral on bone neoformation on the rabbit skull" 8 : 198-207, 1997
• 14 "The TIME technique: a new method for localized alveolar ridge augmentation prior to placement of dental implants" 11 : 387-394, 1996
• 15 "Surgical procedure in the maxilla" 29-45,
• 16 "Surgical Prosthodontic reconstruction of advanced maxillary bone compromise with autogenous onlay block bone grafts and osseointegrated endosseous implants A 12year study of 32 consecutive patients" 14 : 197-209, 1999
• 17 "Supraplant a novel implant system based on the principle of guided bone regeneration" 2 : 199-202, 1991
• 18 "Rigid fixation by means of titanium mesh in edentulous ridge in the maxilla" 13 : 701-705, 1998
• 19 "Regeneration and enlargement of jaw bone using guided tissue regeneration" 1 : 22-32, 1990
• 20 "Qualitative and quantitative comparative study on different filling materials used in bone tissue regeneration.A controlled clinical study" 14 : 195-215, 1994
• 21 "Placement of autogenic bone chips or bovine bone mineral in guided bone augmentation A rabbit skull study" 18 : 795-806, 2003
• 22 "Membrane permeability is unnecessary for guided regeneraion of new bone.An experimental study in the rabbit" 5 : 125-130, 1994
• 23 "Lokale Osteoplastik mit dem Micro Titan Mesh zur Alveolarkamm Augmentation" 105 : 651-659, 1995
• 24 "Localized ridge augmentation using titanium micromesh" 27 : 287-292, 2001
• 25 "Localized ridge augmentation using guided tissue regeneration in humans" 4 : 203-209, 1993
• 26 "Localized ridge augmentation in dogs:A pilot study using membranes and hydroxyapatite" 61 : 157-165, 1990
• 27 "Lateral ridge augmentation using different bone fillers and barrier membrane application" 12 : 260-269, 2001
• 28 "Inductive substratum for osteogenesis in pellets of particulate bone matrix" 61 : 61-78, 1970
• 29 "Inductive substrates for bone formation" 59-96, clinorthop1968
• 30 "Implant placement and simultaneous periimplant bone grafting using a micro titanium mesh for graft stabilization" 18 : 117-127, 1998
• 31 "Healing pattern of bone regeneration in membrane protected defects.A histologic study in the canine mandible" 9 : 13-29, 1994
• 32 "Healing around implants placed in bone defects treated with Bio Oss" 8 : 117-124, 1997
• 33 "Guided tissue regeneration and endosseous dental implants" 13 : 109-119, 1993
• 34 "Freeze dried bone for maxillary sinus augmentation in sheep" 13 : 581-586, 2002
• 35 "Enhancement of the damaged edentulous ridge to receive dental implants:a combination of allograft and the GORE-TEX membrane" 12 : 97-111, 1992
• 36 "Enhanced bone augmentation by controlled release of recombinant human bone morphogenetic protein2 from bioresorbable membranes" 74 : 865-872, 2003
• 37 "Endosteal implants and iliac crest grafts to restore severely resorbed totally edentulous maxillae:A retrospective study" 20 : 100-110, 1994
• 38 "Eighteen month radiographic and histologic evaluation of sinus grafting with anorganic bovine bone in the chimpanzee" 14 : 361-368, 1999
• 39 "Efficacy of bovine bone mineral for alveolar augmentation a human histologic study" 14 : 775-783, 2003
• 40 "Effects of different osteopromotive membrane porosities on experimental bone neogenesis in rats" 17 : 695-702, 1996
• 41 "Effect of GBR in combination with deproteinized bovine bone mineral and or enamel matrix proteins on the healing of critical size defects" 15 : 101-111, 2004
• 42 "Distraction osteogenesis in maxillofacial surgery using internal devices Review of five cases" 54 : 45-53, 1996
• 43 "Deproteinized bovine bone used as an adjunct to guided bone augmentation An experimental study in the rat" 3 : 156-165, 2001
• 44 "Creation of new bone by an osteopromotive membrane technique.An experimental study in rats" 51 : 892-897, 1993
• 45 "Comparison of bone regeneration with the use of mineralized and demineralized freeze dried bone allografts a histologic and histochemical study in man" 17 : 1127-1131, 1996
• 46 "Clinical and histologic evaluation of bone replacement grafts in the treatment of localized alveolar ridge defects" 23 : 29-35, 2003
• 47 "Clem DSC III Reiser GM Buser DA Implants in regenerated bone long term surivial" 18 : 35-45, 1998
• 48 "Bone regeneration around titanium implants in dehised defect sites.A clinical study" 7 : 233-245, 1992
• 49 "Bone regeneration adjacent to titanium dental implants using guided tissue regeneration:a report of two cases" 5 : 9-14, 1990
• 50 "Bone formation utilizing titanium reinforced barrier membranes" 15 : 57-69, 1995
• 51 "Bone formation by autoinduction" 150 : 893-899, 1965
• 52 "Bone augmentation by means of a stiff occlusive titanium barrier" 14 : 63-71, 2003
• 53 "Bone augmentation at fenestrated implants by an osteopromotive membrane technique.A controlled clinical study" 2 : 159-165, 1991
• 54 "Autogenous red marrow grafts:Potential for induction osteogenesis" 40 : 492-497, 1969
• 55 "Augmentation of the rat mandible using guided tissue regeneration" 5 : 75-82, 1994
• 56 "Augmentation of the rat jaw with autogeneic cortico cancellous bone grafts and guided tissue regeneration" 13 : 192-202, 2002
• 57 "Augmentation of the mandible with GTR and onlay cortical bone grafting" 13 : 175-184, 2002
• 58 "Augmentation of intramembraneous bone beyond the skeletal envelope using an occlusive titanium barrier" 6 : 67-72, 1995
• 59 "Augmentation of calvarial tissue using nonpermeable silicone domes and bovine bone mineral" 10 : 468-476, 1999
• 60 "Alveolar ridge augmentation by combining autogenous mandibular bone graft and nonresorbable membranes" 13 : 185-191, 2002
• 61 "A technique for osseous restoration of deficient edentulous maxillary ridges" 43 : 87-91, 1985
• 62 "A decade of technology development for guided tissue regeneration" 64 : 1129-1137, 1993
• 63 "A comparative study of anorganic xenogenic bone and autogenous bone implants for bone regeneration in rabbits" 14 : 72-76, 1999