지방내 혈관내피세포의 염증 기전 = Mechanism of endothelial cell inflammation in adipose tissue

국문 초록 (Abstract)

본 연구는 비만에 의해 증가된 지방내의 염증 반응이 혈관내피세포를 활성화 시키는 기전과 염증으로 인해 활성화된 혈관내피세포의 기능 그리고 혈관내피세포와 지방내의 다른 세포들이 어떠한 상호작용을 하는지를 알아보는데 있다. 지방 조직은 단순한 에너지를 축적하는 장기가 아니라 신체 전반의 항상성을 조절하는 내분비적 기능 및 면역 기능에도 기여한다. 특히 비만은 중등도의 만성적인 염증과 관련이 있으며 이는 제2형 당뇨, 고혈압 및 관상동맥질환을 직접 또는 간접적으로 일으키는 위험인자이다. 비만과 관련된 염증은 지방내의 대식세포의 숫자를 증가시키고 염증 유발성 싸이토카인의 분비를 증가시킨다. 대식세포를 통해 분비된 다양한 염증 유발성 싸이토카인은 지방내의 혈관내피세포를 활성화 시켜 혈액으로부터 백혈구를 조직 내로 침투시킨다. 침투된 백혈구 중 특히 단핵세포는 다시 대식세포로 조직 내에서 분화하여 염증성 싸이토카인을 분비함으로써 만성적 염증 유발에 기여하게 된다. 혈관내피세포의 활성화에 관여하는 염증 유발성 싸이토카인으로써는 TNF-α, IL-6 그리고 IL-1 등이 있으며, 활성화된 혈관내피세포는 백혈구를 침투시키기 위해 각종 adhesion molecule을 분비하게 된다. 따라서 지방 조직내의 혈관내피세포의 염증 반응은 많은 세포들의 상호작용에 의한 복합적인 메커니즘에 의해 발생한다.

다국어 초록 (Multilingual Abstract)

The purpose of this review is to understand the mechanism of endothelial cell(EC) activation induced by inflammation which is occurred in adipose tissue of obese patients. Low-grade of systemic inflammation is intensively linked with excessive development of adipose tissue and leads to onset of several disease like insulin resistance, Type2 diabetes or atherosclerosis. Also it is associated with recruitment of more macrophage into the fat tissue. Macrophage in adipose tissue is regarded as a major source for inflammatory cytokines which activates many cells including adipocytes and EC etc. Once ECs are activated by TNF-α, IL-6 or IL-1, adhesion molecules(ICAM-1. VCAM-1, MCP-1 etc) expressed on endothelial cell recruit leukocytes by binding their ligands of leukocyte. Infiltrated monocytes are differentiated to macrophage in the tissue and express many inflammatory cytokines again. After all, the activation of EC in adipose tissue is related with various stimuli which is occurred through the cross-talk between all the cells in adipose tissue.

목차 (Table of Contents)

• 서론 면역세포의 침투 대식세포(Macrophage) 아디포카인(Adipokines)과 염증 비만에 대한 지방 내 혈관내피세포의 반응 결론

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