Vincristine이 생쥐 신장의 효소활성에 미치는 영향에 관한 조직화학적 연구 = Histochemical Study on Effect of Vincristine upon Renal Enzymes in Mice

국문 초록 (Abstract)

미정맥으로 투여한 vincristine은 생쥐의 근위곡 요세관 상피의 효소활성에 크게 영향을 미쳐 투여 1일 후에는 cytochrome oxidase, lacatate dehyrogenase, glucose-6-phosphate dehydrogenase의 활성이 감소되기 시작하였고 투여 4일 후에는 효소 활성 저하가 현저하였으며, 이때부터 alkaline phosphatase 활성은 저하되기 시작하였고 acid phosphatase의 활성은 증가하기 시작하였다.

다국어 초록 (Multilingual Abstract)

This experiment was carried out to investigate the effect of vincristine upon renal enzymes in mice. The laboratory animals were administered with single dose of vincristine 0.1mg/kg by the intravenous injection.
Histochemical studies observed the activities of cytochrome oxidise, alkaline phosphatase, acid phosphatase, lactate dehydrogenase and glucose-6-phophate dehydrogenase .
The following results were obtained:
1.The activities of cytochrome oxidase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase began to be decreased from the 1st day in the proximal tubules. After the 4th day, these decreased were salient and at the 9th day these activities were slightly resilient in the proximal tubules.
2.From the 4th day, the alkaline phosphatase activity began to be decreased and the acid phosphatase activity to be increased, these activities were maintained at the 15th day.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 실험성적
• 1) Cytochrome oxidase
• 2) Alkaline phosphatase
• 3) Acid phosphatase
• 4) Lactate dehydrogenase
• 5) Glucose-6-phosphate dehydrogenase
• 고찰
• 결과