임신말 모체와 제대혈의 retinol, b-carotene, a-tocopherol 의 농도 및 임신결과와의 상관성 = Retinol, b-carotene and a-tocopherol concentrations in maternal-umbilical cord plasma and their relationships to pregnancy outcome

다국어 초록 (Multilingual Abstract)

The purpose of this study was to evaluate the intake of antioxidant vitamins and plasma concentrations of those in 60 maternal-infant pairs (30 in normal term delivery group, NT; 30 in preterm delivery group, PT). We also investigated the relationship between vitamin levels of maternal-umbilical cord plasma and pregnancy outcome. Mean energy intakes of NT and PT pregnant women were 93.2% and 85.4%, and their protein intakes were 113.3% and 110.9 % of the recommended dietary allowance (RDA), respectively. While vitamin A intakes were only 51.2% and 39.6% of the RDA in NT and PT pregnant women. The vitamin E intake was about 50% of the RDA (NT 6.27 mg, PT 7.78 mg). The levels of retinol in maternal plasma of NT and PT were 1.51 μmol/ℓ and 1.43 μmol/ℓ, respectively. The retinol levels in umbilical cord plasma in NT and PT were 0.72 μmol/ℓ and 0.61 μmol/ℓ, respectively. The level of β-carotene in maternal plasma of NT was 0.49 μmol/ℓ, significantly (p < 0.01) higher than that of PT (0.31 μmol/ℓ). The β-carotene of umbilical cord plasma of NT and PT were 0.02 μmol/ℓ and 0.01 μmol/ℓ, respectively. The plasma αtocopherol of maternal of NT and PT were 29.51 μmol/ℓ and 27.17 μmol/ℓ, respectively. The α-tocopherol of umbilical cord plasma of NT and PT were 4.16 μmol/ℓ and 3.80 μmol/ℓ, respectively. The antioxidant vitamin levels (retinol, β-carotene, and α-tocopherol) in maternal plasma were significantly higher (p < 0.0001) than those in umbilical cord plasma. However, there was no correlation between the vitamin levels in maternal plasma and those in umbilical cord plasma. The maternal plasma β-carotene level showed a positive correlation to gestational age. Also Apgar score at 1 min produced a positive correlation to maternal plasma β-carotene level. (Korean J Community Nutrition 9(2) : 151 ~ 160, 2004)

참고문헌 (Reference)

• 1 "efficacy of vitamin E in a double-blind clinical study of preterm infants" 1365-1371, 1981
• 2 "and the Oxygen radical disease of prematurity" 1341-1344, 1988
• 3 "and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multi-wavelength detection" re-ti (re-ti): 411-416, 1994
• 4 "administration and metabolism in very low birth weight infants" reti (reti): 170-180, 1992
• 5 "Vitamin E in neonatology" 127-147, 1986
• 6 "Vitamin A status of the newborn in relation to gestational age" 794-780, 1984
• 7 "Vitamin A status in preterm and term infants at birth. J Perinat Med 21" 59-62, 1993
• 8 "Vitamin A and related essential nutrients in cord blood relationships with anthropometric measurements at birth" 177-188, 1994
• 9 "Trabajo de parto premature infeccion intraamnostica: aspectos dlinicos y funcion de las citocinas en el diagnostico y la fisiopato- logia" 2 : 267-326, 1995
• 10 "Total plasma antioxi- dant capacity predicts thrombosis-prone status in NIDM patients" 20 (20): 1589-1593, 1997
• 11 "Total antioxi-dant status in maternal and neonatal plasma according to delivery type" 41 (41): 2067-2071, 1998
• 12 "The vitamin status of low birth weight infants and their mothers" 744-748, 1981
• 13 "The efects of regular exercise on nutrients intake and pregnancy outcome of pregnant women in daegu area." 34 (34): 929-935, 2001
• 14 "Synthesis of 1 25-Dihydroxyvitamin D3 by Hu-man Placenta in Vitro" j clin endocri (j clin endocri): 484-488, 1981
• 15 "Studies on lipid peroxide of normal pregnant women and of patient with toxemia of pregnancy" Clin Chim Acta 84 1 1-2 9, 1978
• 16 "Some limitation of semiquantitative fod frequancy questionnaire" 1127-1132, 1992
• 17 Coutsoudis A,, "Serum vitamin A (retinol) concenrtations and asociation with respiratory disease in premature infants." 41 (41): 230-233, 1995
• 18 "Serum concentrations of zinc, folate, vitamin A and E, and proteins, and their relation- ships to pregnancy outcome." 165 : 63-70, 1997
• 19 "Riboflavin and pyridoxin nutri-tional status of newborns A multiple regresion analysis of its determing factors" 368-377, 1994
• 20 "Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants" 17 (17): 442-447, 1998
• 21 "Relationship betwen maternal serum vitamin A and vitamin status of the coresponding fetus" 313-315, 1988
• 22 "Reduced survival of neonates due to vitamin A deficiency during pregnancy in the gunia pig. Proc Soc Exp Biol Med 197" 56-58, 1991
• 23 "Preparation for birth into an O2 rich environment the antioxidant enzymes in the developing rabit lung" 240-244, 1984
• 24 "Prenatal development of lung antioxi-dant enzymes in four species" 106-110, 1987
• 25 "Oxidative stres in the neo- nate" 65 : 75-81, 2001
• 26 "Nutritive values of fods selected during pregnancy" 164-167, 1973
• 27 "Nutritional status of rural pregnant women in relation to physical condition of ofspring at birth" 547-56, 1989
• 28 "Nutrition in pregnancy and lactation" Mosby 1993
• 29 "Measurement of serum vitamin E isomers in fullterm and preterm infants" 24 (24): 793-798, 2001
• 30 "Maternal low-dose vitamin A or β-carotene supplementation has no efect on fetal los and early infant mortality: a randomized cluster trial in Nepal" 71 : 1570-1576, 2000
• 31 "Maternal levels of prostcyclin" 1690-1695, 1991
• 32 "Lipid peroxide levels and lipid serum content of serum lipoprotein fractions of pregnant subjects with and without preclampsia" Clin Chim Acta 155 155-160, 1981
• 33 "Iron status in pregnant women and their newborn infants" 32 (32): 793-801, 1999
• 34 "Free radical disorders of preterm infants" 668-678, 1993
• 35 "Evaluation of a pediatric multiple vitamin preparation for total arenteral nutrition Blood levels of vitamin A" 539-77 547, 1986
• 36 "Efects of regular pysical execise habits on the activities of erythrocyte antioxidant enzyme and plasma total radical-traping antioxidant potential in healthy male subjects." 33 (33): 289-295, 2000
• 37 "Efects of maternal anemia on the iron status of the cord blood and pregnancy outcomes" 3 (3): 565-573, 1998
• 38 "Efect of maternal status on imu-nological substances in breast milk of Korean women" 263-271, 1994
• 39 "Dietary fat intake during pregnancy and serum lipid levels in mother and umbilical cord of full-term and preterm delivery" 32 (32): 577-584, 1999
• 40 "Corelation of levels of hemoglobin and hematocrit with nutritional intakes and general environmental fac-tors of pregnant women among low income group in Seoul area" 51-64, 1983
• 41 "Cord blood concentrations of vitamin A in preterm infants." 56 : 39-47, 1999
• 42 "Concentrations of tocopherols and carotenoids in maternal and cord blood plasma" 53 (53): 711-715, 1999
• 43 "Asesment of the intake and availability of dietary iron and nutrition knowledge in pregnant women" 3 (3): 53-61, 1998
• 44 "Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status" 33 (33): 276-280, 2002
• 45 "Antioxi- dant capacity and oxygen radical disease in the preterm newborn." 154 : 544-548, 2000
• 46 "Afood and nutrient intake of the pregnant women in rural Korea" 197819-25
• 47 "A study on the nutritional status of the pregnant and the lactating women and the newborn babies in Samchuk-Gun district A thesis for a Doctorate" Ewha Womens University 1982
• 48 "A novel method for measuring antioxidant capacity and its appli-cant to monitoring the antioxidant status in premature neonates 84" 407-412, 1993
• 49 "A cross-sectional study of nutrient intakes by gestational age and pregnancy outcome (I)." 32 (32): 877-886, 1999
• 50 "A cross-sectional study of biochemical analysis and assessment of iron deficiency by gestational age (II)." 32 (32): 887-896, 1999