비접촉식 경면현미경을 이용한 20대의 각막내피세포 분석 = Analysis of Corneal Endothelial Cells Measured by Noncontact Specular Microscopy in 20s

국문 초록 (Abstract)

목적 : 건강한 20대를 대상으로 각막내피세포의 형태학적 분석을 실시하고, 양안, 성별, 굴절교정수술 여부, 콘택트렌즈 착용여부, 코로나바이러스-19의 감염에 따른 차이를 알아보고자 하였다.
방법 : 충청남도 일개 대학교에서 20대 남녀 87명(174안)을 대상으로 하였다. 각막내피세포의 형태학적 분석은 비접촉식 경면현미경을 이용하여 검사하였고, 각막내피세포의 밀도, 내피세포의 다형성, 육각형비율, 그리고중심각막두께를 분석하였다. SPSS 18.0 프로그램을 이용하여 양안, 성별, 그리고 그 외에 조사한 변수에 따른 각막내피세포의 밀도, 다형성 및 육각형 비율을 측정하였다.
결과 : 우안과 좌안에서 각막내피세포의 밀도는 각각 2,977.7±238.7 cells/mm2와 3,008.9±236.7 cells/mm2(p=0.056)이었고, 남성과 여성은 각각 2,970.9±237.9 cells/mm2와 2,983.6±241.8 cells/mm2로 통계적으로 유의한 차이가 없었다(p=0.807). 각막내피세포의 다형성과 육각형 비율도 양안, 성별, 굴절교정수술 여부. 코로나바이러스-19 감염 유무에 따라 유의한 차이가 없었다(p>0.050). 그러나 각막내피세포의 다형성과 육각형 비율은 콘택트렌즈 착용 군과 대조군에서 각각 30.7±4.5%와 61.9±5.4% 그리고 28.2±4.0%와 64.7±4.7% 를 보였다(각각 p=0.018와 p=0.029).
결과 : 한국 20대 성인을 대상으로 분석한 각막내피세포 밀도의 평균값은 2,993.3±237.5 cells/mm2이었고, 양안과 성별에 따른 차이는 없었다.

다국어 초록 (Multilingual Abstract)

Purpose : Morphological analysis of corneal endothelial cell was conducted in young adults Korean in their 20s, and differences according both eyes, sex, refractive surgery, contact lenses, COVID-19 infection were investigated.
Methods : A total of 87 (174 eyes) men and women in their 20s were enrolled in a university in Chungcheongnam-do. Morphological analysis of corneal endothelial cell was examined using a noncontact specular microscopey, and corneal endothelial cell density, endothelial cell polymorphism, hexagonal ratio, and central corneal thickness were analyzed. The SPSS 18.0 program was used to compare differences in corneal endothelial cell density, pleomorphism, and hexagonal ratio according to both eyes, sex, and other variables investigated.
Results : The density of corneal endothelial cell was 2,977.7±238.7 cells/mm2 in the right eye and 3,008.9±236.7 cells/mm2 in the left eye (p=0.056). Men had 2,970.9±237.9 cells/mm2 and women had 2,983.6±241.8 cells/mm2, and there was no statistically significant difference (p=0.807). Polymorphism and hexagonal ratio of corneal endothelial cell were also not significantly different according to both eyes, sex, refractive surgery, COVID-19 infection (p>0.050). However, the polymorphism and hexagonal ratio of corneal endothelial cell according to whether or not they wore contact lenses were 30.7±4.5% and 61.9±5.4% in the contact lens wearing group and 28.2±4.0%, and 64.7±4.7% in the control group (p=0.018 and p=0.029, respectively).
Conclusion : The average value of corneal endothelial cell density analyzed in Korean in their 20s was 2,993.3±237.5 cells/mm2, and there was no difference between both eyes and sex.

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