下顎骨 缺損部의 數種方法에 依한 自家骨移植 및 人工骨材料 移植後의 治癒過程에 關한 比較實驗的 硏究 = Comparative Experimental Studies on Healing Process of Various kinds of Bone Grafts and Alloplastic grafts in Rabbit Mandibular Defect Area

다국어 초록 (Multilingual Abstract)

Healing process of fresh autogenous iliac bone (as a control group) and Particulated Cancellous Bone & Marrow, Frozen bone, Autoclaved bone grafting, PHDPE and HAP block graft in to the inferior border of the mandible were observed histologically in rabbits.
Results
1. One week after grafting, new bone formation was formed in walls of medullary cavity near the cut end of both the host and grafted bone.
Coagulation nets, inflammatory cell infiltration, the proliferation of fibroblast was found. Vascularization to medullary cavity of the grafted bone started.
In case of PCBM graft group was found osteoclastic activity only.
In case of alloplastic grafts, blood clot, fibroblast and mild inflammatory reaction were observed.
2. Two weeks after grafting, new bone formation was apparent in outer surface and cut end of host bone and the grafted bone.
New bone formation occurred earlier in the PCBM graft group than in block bone graft. In case of alloplastic graft, new bone formation started in PHDPE pore near host bone and in host bone adjacent to HAP block. Fibroblast was proliferated in both group.
3. Four weeks after grafting of block bone and PCBM, widened haversian canal was partially observed. And new bone formation, started on the host bone, and bony union between host and graft was complete four weeks after transplantation. New bone formation area of frozen autogenous bone graft was more wide than that of frozen autogenous bone graft was more wide than that of autoclaved bone graft. In case of alloplastic graft, new bone formation was more apparent in both group. Newly formed bone of HAP block graft group showed more maturity than that of PHDPE graft group.
4. Grafted bone into mandibular defect area is gradually resorbed and replaced by new bone from at second or fourth week. In HAP block graft group, direct bony union between HAP surface and newly formed bone was revealed partially and haversian canal was observed. In PHDPE graft group, pore was almost completely filled with newly formed bone.