中樞神經興舊性 藥物이 Aspirin의 藥物動力學的 效果에 미치는 影響에 關한 硏究 = Studies on the effects of CNS stimulants to the biopharmacokinetics of Aspirin

다국어 초록 (Multilingual Abstract)

Studies were made on the biopharmacokinetics of aspirin and concurrent administration of CNS stimulants (ephedrine, caffeine) by examing the blood concentration of rabbits which had been administered them orally.
Simultaneous administration of aspirin and CNS stimulants resulted in an increased absorption rate of aspirin as follows.
The absorption rate percentage at the time of peak concentration, aspirin was 79.45％ at 2hr, with epedrine was 91.2％ at 2hr, and with caffeine was 81.30％ at 1.5hr. And also the absorption rate constant (Ka) of aspirin was altered by CNS stimulants: the Ka of aspirin was 0.518hr, with ephedrne was 1.320hr, and with caffeine was 0.230hr.
The elimination of aspirin was reduced by ephedrine and accelerated by caffeine. The elimination rate constant(Kel) of aspirin was 0.115hr, with ephedrine was 0.046hr, and with caffeine was 0.138hr.
Peak concentrations in blood were achived more quickly by caffeine.
The biological half-life of aspirin was 6.02 hours. It was prolonged by ephedrine to 15.06 hours and reduced by caffeine to 5.02 hours.
The apparent volumes of distribution (Vd) of aspirin were 73.64ml. When aspirin administered with ephedrine, the Vd values were changed to 93.17ml, and with cafferine to 78.87ml.
The area under the curve(AUC) of aspirin was increased by concurrent administration of ephedrine from 42.8 mg/ml · hr to 105.04 mg/ml · hr, and decreased by caffeine to 33.87 mg/ml · hr.
The values of AUC accorded with the inhibition ％ of analgesic effect on acetic acid induced writhing ayndromes.