한국에서의 양극성장애, 정신분열병과 Borna Disease Virus와의 관련성 = The Relation between Human Boma Disease Virus, Bipolar Disorder and Schizophrenia in Korea

국문 초록 (Abstract)

본 연구는 대구, 경북지역에 입원치료 중인 양극성 장애와 정신분열병 환자들을 대상으로 BDV 감염여부를 RT-PCR과 Southern hybridization 방법을 이용하여 알아보았다.
연구 결과 41명의 정상 대조군에서 2명의 p24 양성, 3명의 p40 양성이 나타났다(12.2%). 41명의 양극성 장애환자들에서도 동일하게 2명의 p24양성, 3명의 p40 양성이 나타났다. 그러나 53명의 정신분열병 환자들에서는 3명의 p24 양성, 15명의 p40 양성, 및 p24, p40이 모두 양성인 경우가 1명, 총 17명이 BDV 양성으로 나타났다(32.1%). 정신분열병 환자 중 양성 및 음성증상군에서 각각 31명 중 10명(32.3%), 22명 중 7명(31.8%)이 양성으로 나와 양성과 음성증상군 사이의 차이는 발견할 수 없었다. 본 연구결과에 따르면 BDV는 양극성 장애보다 정신분열병과 더 연관성이 있다고 볼 수 있다.
또한 RT-PCR 산물을 유전자클로닝(cloning)하여 염기서열을 분석한 결과 점돌연변이(point mutaion)와 결손형돌연변이(deletion mutation)들이 나타났다. 특히 대부분의 점돌연변이가 모든 임상 검체에서 동일한 염기로 치환된 것으로 보아 참조한 BDV strain V와는 다른 고유한 strain으로 보인다.

다국어 초록 (Multilingual Abstract)

We studied on the Borna disease viral infection in the patients with bipolar disorder or schizophrenia, who live in Taegu City or Kyungpook Province, Korea by using sequence analyses of RT -PCR and Southern hybridization.
As a result, among 41 normal control, 2 shows positive result for p 24 and 3 for p40(12.2%). Similarly, among 41 patients with bipolar disorder, 3 shows positive result for p24 and 3 for 40. But among 53 schizophrenic patients, 3 shows positive result for 24, 15 for p40, and 1 for both, which showed that total 17 patients were positive(32.1%). So, it seems that BDV is more related to schizophrenia than bipolar disorder. In this study, negative syndrome group (31.8%) in schizophrenics is similar to positive syndrome group(32.3%) in positive response to BDV.
Besides, point mutations and deletion mutations were found by the sequence analysis of RT-PCR products. It seems that the BDVs isolated in Korea are peculiar ones which is different from strain V to which we referred, because most point mutations represented that the same bases were especially substituted in every clinical samples.

목차 (Table of Contents)

• 영어 초록
• 서론
• 대상 및 방법
• 결과
• 고찰
• 요약
• 참고문헌

참고문헌 (Reference)

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