Thiopental Sodium의 痲醉作用 및 2,3 物質代謝에 미치는 Carbon Tetrachloride와 Adrenocorticotropic Hormone의 影響 = The Influences of Carbon Tetrachloride and Adrenocorticotropic Hormone on the Anesthetic and Metabolic effect of Thiopental Sodium

다국어 초록 (Multilingual Abstract)

In order to investigate the influences of CCl₄ and ACTH on the anesthetic and metabolic effects of thiopental sodium, following experimental studies had been carried out with albino rabbits.
The anesthetic effect of thiopental sodium was observed by measuring the induction time, anesthetic time, recovery time and duration from the beginning of induction to the recovery of anesthesia (total time), respectively, and the metabolic effects of thiopental sodium was studied by measuring the blood sugar concentration and serum transaminase (GOT, GPT) activities in the rabbits pretreated with CCl₄ and ACTH.
In addition to those experiments, catecholamine contents of cerebrum of rabbits was measured after injection of CCl₄ and ACTH.
The results were obtained as follows:
1. The induction time of anesthesia by the injection of thiopental sodium was shortened by the pretreatment of CCl₄ but the anesthetic time, recovery time and total time of anesthesia were markedly delayed.
2. The induction time of anesthesia by the injection of thiopental sodium was shortened by the pretreatment of ACTH for one day but anesthetic time was delayed. The induction time and recovery time of anesthesia by the injection of thiopental sodium were shortened by the pretreatment of ACTH for one week.
3. The catecholamine contents of cerebrum of rabbit were not influenced by the CCl₄, injection, but markedly increased by the ACTH injection for one week.
4. The blood sugar concentration and serum GOT activity were not influenced by the thiopental sodium injection but serum GPT activity was markedly increased. However, the pretreatment of CCl₄ followed by thiopental sodium injection decreased the blood sugar concentration but increased serum GOT and GPT activities.
5. The pretreatment of ACTH for one day followed by thiopental sodium injection increased the blood sugar concentration but decreased GOT and GPT activities.
6. The pretreatment of ACTH for one week followed by thiopental sodium injection showed the tendency to decrease the blood sugar concentration, serum GOT and GPT activities.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗材料 및 方法
• Ⅲ. 實驗成績
• A. 痲醉作用에 對한 效果
• B. 大腦皮質中 catecholamine 含量
• C. 血糖量
• D. 血淸 transaminase 活性度
• Ⅳ. 考察
• Ⅴ. 結論
• 參考文獻