피부종양에서 암유전자들의 상호관계에 대한 면역조직화학적 연구 = An Immunohistochemical Study of Oncogene Interaction in Skin Tumors피부종양에서 암유전자들의 상호관계에 대한 면역조직화학적 연구

다국어 초록 (Multilingual Abstract)

Background : Alteration of a wide variety of cellular oncogerms have now been implieated in the causation of many human cancers. However, genetic studies have indicated that an abnormality of a single gene is usually insufficient to elicit the fug transformed phenotype and that two or more genetic leaions may be necessary for this to occur Object : The purpose of this study is to examine the possibity of oncogene interaction which might be involved in the pathogenesis of human skin tugois. Methods : The expression of the epidermal growth factor rattor(EGFR), c-jun protein, c-fos protein and p53 protein was assessed in frozen and corresgoAhng paraffin-embedded sections of 37 separate skin lesions (6 actinic keratoses, 6 squamo is ell carcinomas and 25 basal cell carcinomas using immunohistochemistry. Results : Substantial number of the p53 positive cases were negative for c-fos, in contrast to normal tissue, which was p53 negative and c-fos positive. The negative correlation between p53 and c-fos staining was statistically significant(P<0.005). Conclusion : Although p53 appeared to have lost its normal role of regulatory early S phase protein in some lesions, in others high levels of p53 were assocated with underexpression of c-fos, reflecting the diversity of c-fos oncogene and the possible down regulation of c-fos expression by high levels of p53 protein.
(Kor J Dermatol 1994, 32(6): 962-970)