유방감마스캔을 이용한 유방암 검진 = Breast-Specific Gamma Imaging in Breast Cancer Screening

다국어 초록 (Multilingual Abstract)

The sensitivity and specificity of breast cancer screening with mammography in dense breasts are very low, and increasing attention has been paid to breast density and screening in highrisk groups. Therefore, a supplemental screening modality is needed. Mammography and supplementary ultrasound screening are mainly based on the differences between cancerous and normal breast parenchyma on an anatomical basis, whereas breast-specific gamma imaging is a functional imaging approach examining the physiological phenomena of blood flow and mitochondrial activity, which are increased in cancer cells. The purpose of this review is to discuss the diagnostic methods, clinical results, clinical application, and considerations of breast cancer screening with breast-specific gamma imaging using 99mTc-sestamibi.

국문 초록 (Abstract)

치밀유방에서의 유방촬영술은 민감도와 특이도가 매우 낮으며 유방의 치밀도와 고위험군에서의 유방암 검진에 대한 관심이 높아지고 있다. 이에 유방촬영술의 보조적인 영상검사가 필요하다. 유방촬영술이나 초음파검사는 주로 유방암과 정상 유방 실질의 해부학에 근거한 영상검사인데 비해 방사성동위원소를 이용한 유방감마영상은 생리학적인 기반으로 암세포에서 증가된 혈류와 미토콘드리아 활성화에 의해 유방암을 진단한다. 본 종설에서는 99mTc-sestamibi를 이용한 유방감마영상의 유방암 검진에 관한 검사방법, 임상연구 결과, 임상 적용, 영상 판독 기준 및 유방암 검진에서의 문제점에 관하여 알아보고자 한다.

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