Toxoplasma 면역모체로 부터 출산된 신생마우스에 있어서 Vaccination 효능 저하 = Failure of Toxoplasma - Vaccination in Mice Born to Immune Mothers

다국어 초록 (Multilingual Abstract)

Female ICR mice were vaccinated against I'oxoplasma gondii(RH strain), infected 2 weeks later and af- ter recovery mated to normal ICR males. Control matings were with normal ICR ferna)es. The progeny of the above matings were weaned at 1 week, vaccinated at 1, 2, 3, 4 or 5 weeks of age and infected 2 weeks later with lethal 1'oxoplasnw tachyzoites.
As assessed hy survival, the effectiveness of vaccination among offspring of vaccinated-recovered mothers was greatly impaired than that of control mice, with respective of age: where mice did survive, recovery was greatly delayed relative to the controk
The protective effect of vaccination arnong infants bom to control mothers was also blocked by mater- nal specific antibodies, by adtninistration of high-titered specific antibodies or by transfer of nylon wool ad- herent imrnunc-spleen cells, but was augmented hy transfer of nylon wool p;med immune-spleen cells.
These results indicate that this impairment of vaccination may be due to the transmission of matemal sp- ecific antibodies to the offspring which acts to suppress both primmg by the vaccine and the generation of parasite-specific helper T cells.