치매를 나타내지 않는 인슐린 비의존성 당뇨환자에서 인지유발전위 = Event-Related Evoked Potentials in Non-Demented Patients with Non-Insulin Dependant Diabetes Mellitus

다국어 초록 (Multilingual Abstract)

Background : Cognitive impairment has been recognized as a possible complication of diabetes mathtus (DM). It is well known that event-related potentials (ERPs) and Hopkins verbal Leaming Test (HVLT) are clinical tools in the evaluation of the patients who suffer from disorders of congnition. The present study was designed to investigate the effect of diabetes meltus and its complications on the ERPs nad HVLT. Methods : A cross sectional comparative study of the 51 normal controls and the 40 non-demented NIDDM patients who had no neurologic deficits was performed. The study consisted of a neurologic examination. Short form-Samsung Dementia Questionnaire brain CT. ERPs, HVLT, nerve conduction study, fundus examination and biochemical study Results : The P300 latencies of the DM patients and the normal control groups were well correlated with age Compared with controls, the P300 latencies of the patients were signficantly prolonged In NIDDM patients, prolonged P300 latencies were not associated with neuropathy but with retinopathy (p<.05) P300 latencies of NIDDM were correlated with immediate free recail of HVLT. There were no significant differences in scores of HVLT components between NIDDM and normal control group Conclusions : NIDDM patients without overt dementia or other CNS disorders may have a subtle cerebral malfunction, which can be detected by ERPs but not by verbal learning test. Therefore ERPs might be a useful tool to evaluate subtle cognitive dysfunction It is suggested that the factors responsible for genesis of this cerebral malfunction are not influenced by short-term metabolic dysfunction and may be different from those responsible for the DM neuropathy.