만성 신부전 환자에서의 대장점막 Angiotensin-converting Enzyme의 활성도 = Angiotensin-converting Enzyme Activity in the Colonic Mucosa of Chronic Renal Failure

국문 초록 (Abstract)

만성 신부전 환자는 신장의 기능이 저하함에 따라 체내 칼륨의 평형을 유지하기 위해 대장에서의 칼륨의 배설이 증가되는데, 만성 신부전 환자 5명의 대장점막에서 rennin-angiotensin system의 중요한 역할을 담당하는 angiotensin-converting enzyme의 변화를 spectrophotometry로 관찰한 결과, 상행 결장, 횡행 결장 및 하행 결장 모두에서 정상대조군 8명과 비교하여 활성도 차이가 관찰되지 않았으며, 각 부위간의 차이도 관찰되지 않았다.

다국어 초록 (Multilingual Abstract)

The renin-angiotensin system (RAS) is involved in the maintenance of the blood pressure and electrolyte balance. They consist of circulating and local RAS. The former originated from kidney, but the latter exist in central and peripheral nervous system, adrenal gland, heart and gastrointestinal tract. Chronic renal failure patients compensate the hyperkalemia partially by increased secretion of potassium through the large intestine. So, it is suggested that the angiotensin-converting enzyme (ACE) which has important role in potassium metabolism through the local RAS, might be altered in the colonic mucosa of chronic renal failure patients. Then the activity of ACE in the colonic mucosa of 5 patients of chronic renal failure and 8 persons of normal control were measured spectrophotometrically, which was analysed statistically by Mann Whitney test. The activity of ACE in the colonic mucosa from chronic renal patients and from normal controls measured as 11.2±6.7nM/min/mg, 6.7±1.37nM/min/mg in ascending colon, 5.6±5.1 nm/min/mg, 8.1±2.1nM/min/mg in transverse colon, and 7.5±3.5nM/min/mg, 8.2±2.9 nM/min/mg in descending colon respectively. The ACE activity was not significantly different between each group and between each site of colon.
So, it is suggested that the local system of RAS of colonic mucosa do not act main role for potassium metabolism in chronic renal filure patients. To assess the role of circulating and local RAS in chronic reanl failure patients, it is necessary to evaluate simultaneous measurement of two systems with strict consideration of other factors, such as calcium and other electrolytes status.

목차 (Table of Contents)

• 서론
• 대상 및 방법
• 1.대상
• 2.방법
• 결과
• 1.대장 점막 ACE 활성도(Fig. 1)
• 2.대장 점막 Alkaline phosphatase 활성도(Fig. 2)
• 3.대장 점막 Aminopeptidase N 활성도(Fig. 3)
• 고안
• 결론