SCOPUS
KCI등재
SCIE
섬유소원융해시 생성되는 펩타이드가 백서 신기능에 미치는 영향
저자
김성권 (서울대학교 의과대학 내과학교실) ; 이정상 (서울대학교 의과대학 내과학교실) ; 오하영 (한림대학교 의과대학 내과학교실)
발행기관
학술지명
Kidney Research and Clinical Practice(Kidney Research and Clinical Practice)
권호사항
발행연도
1989
작성언어
Korean
KDC
513.000
등재정보
SCOPUS,KCI등재,SCIE
자료형태
학술저널
발행기관 URL
수록면
19-35(17쪽)
제공처
소장기관
Ancrod has been known effective in improving renal function in animal studies and cases of human glomerulonephritis. This effect was more prominent in high FDP groups. It has been thought that the effect is mediated by improved renal perfusion following fibrinolysis of fibrin deposits or by immunosuppressive actions of fibrin degradation product (FDP) released during fibrinolysis, but it also seems that FDPs may play a direct role in improving renal function.
In order to evaluate the direct effects of peptides released during fibrinolysis, a renal function study was performed using Sprague-Dawley rat by injecting control sera (Exp. 1) and fibrinogen degradation product (fdp) derived from plasmin digestion of fibrinogen (Exp. 2).
The results were as the following.
1) Urine volume/gram kindey weight
There was no change in Exp. 1, but it increased from 5.19±0.54 ml/min-g to 11.47±2.37 ml/min-g in Exp. 2 (p$lt;0.01), The ratio of the basal to experimental values also increased in Exp. 2, compared with Exp. 1p $lt; 0.01).
2) Creatinine clearance/gram kidney weight
There was no change in Exp. 1, but it increased from 1.11±0.06ml/min g to 1.46±0.14ml/min-g in Exp. 2 (p$lt;0.01$gt;. No change in the ratio of the basal to experimental values between Exp. 1 and Exp. 2 was noted.
3) Urine electrolytes/gram kidney weight
(1) Urine electrolyte concentrations/gram kidney weight
Urine sodium concentration did not change in Exp. 1, but it increased from 23.9±10.1 mEq/ml g to 62.1±14.7 mEq/ml.g in Exp. 2 (p$lt;0.01). The ratio of the basal to experimental values also increased in Exp. 2, compared with Exp. 1 (p$lt;0.05).
Urine potassium concentration did not change in Exp. 1, but it decreased from 70.6± 10.7 mEq/ml g to 42.2±5. 0 pEq/ml g in Exp. 2 (p$lt;0.05). No change in the ratio of basal to experimental values between Exp. 1 and Exp. 2 was observed. Urine chloride concentration, on the other hand, increased from 37.7±6.5 mEq/ml g to 65.1±9.4 mEq/ml g in Exp. 1 (p $lt; 0.05) and from 33.8± 8.8 m Eq/ml.g to 73.7± 11.1 mEq/ml-g (p$lt;0.01) as well. But no change in the ratio of the basal to experimental values between Exp. 1 and Exp. 2 was noted.
(2) Urine electrolyte excretions/gram kidney weight As for urine sodium excretion, no change was noted in Exp. 1, but it increased from 0.25±0.14 mEq/min g to l. 30±0.54 mEq/min-g in Exp. 2 (p$lt;0.01). The ratio of the basal to experimental values also increased in Exp. 2, compared with Exp. 1 (p$lt;0.01).
No change in urine potassium excretion occurred in either Exp. 1 or Exp. 2. Urine chloride excretion increased from 0.48±0.11 mEq/min g to 1.02±0.23 mEq/min g in Exp. 1 (p$lt;0.05) and from 0.32±0.11 mEq/min g to 15.3±0.46 m Eq/min g in Exp. 2 (p$lt;0.01) as well. The ratio of the basal to experimental values also increased in Exp. 2, compared with Exp. 1 (p$lt;0.01).
4) Electrolyte clearances/gram kidney weight
Sodium clearance increased from 3.0±0.8 ml/min g to 6.9±1.9 ml/min g in Exp. 1 (p$lt;0.05) and from 2.0±0.7 ml/min g to 7.3±1.8 ml/min g in Exp. 2 (p$lt;0.01$gt;. Potassium clearance did not chaner Exp. 1, or Exp. 2.
Chloride clearance also did not changs in Exp. 1, but it increased from 2.7±0.9 ml/min-g in Exp. 2 (p$lt;0.01). The ratio of the basal to experimental values in sodium and chloride increased in Exp. 2, compared with Exp. 1 (p$lt;0.05).
5) Fractional excretion of electorlytes
As for sodium and chloride, fraction excretion did not change in Exp. 1, but it increased in Exp. 2, from 0.14+ 0.08% to 0.48±0.10% for sodium (p$lt;0.01), and from 0. 24±0.08% to 1.08±0.32% for chloride (p$lt;0.01).
Also, the ratios of the basal to experimental values for sodium and chloride did not change in Exp. 1, but increased in Exp. 2.
As for potassium, no changes in fractional excretion and the ratio of basal to experimental values were noted in either Exp 1 or Exp 2.
6) Serial changes in selected variables of renal func- tion in Exp. 2
Urine volume, creatinine clearance, urine sodium and chloride excretions began to increase in 20 minutes after fdp injection and it persisted till the end of experiment, but urine potam excretion was unchanged.
In summary, fdps cause a slight increase in creatinine clearance and marked increases in the urine volume and urinary excretion of sodium and chloride. These find- ings support that fdps have direct effects on the renal function, and it is strongly suggested that the renal tubules are involved in the manifestation of such effects. Further investightion is warranted for identification of the mechanism and the specific FDP peptides responsible for the observed changes in this study.
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