Human disease-related long noncoding RNAs: Impact of ginsenosides

다국어 초록 (Multilingual Abstract)

Ginsenosides in ginseng are known for their potential health benefits, including antioxidant properties and theirpotential to exhibit anticancer effects. Besides a various range of coding genes, ginsenosides impose their efficacyby targeting noncoding RNAs. Long noncoding RNA (lncRNA) has gained significant attention from both basic and clinical oncology fields due to its involvement invarious cancer cell activities such as proliferation, apoptosis, metastasis, and autophagy. These events can beachieved either by lncRNA alone or in association with microRNAs or proteins. This review aims to summarizethe diverse activities of lncRNAs that are regulated by ginsenosides, focusing on their role in regulating targetgenes through signaling pathways in human diseases. We highlight the results of studies on the expressionprofiles of lncRNAs induced by ginsenosides in efforts to inhibit cancer cell proliferation. Finally, we discuss thepotential and challenges of utilizing lncRNAs as diagnostic markers for disease treatment.