Normal saline and polydeoxyribonucleotide injection plus 308 nm excimer laser for treatment of steroid induced hypopigmentation and lipoatrophy: Report of 6 cases = Normal saline and polydeoxyribonucleotide injection plus 308 nm excimer laser for treatment of steroid induced hypopigmentation and lipoatrophy: Report of 6 cases

다국어 초록 (Multilingual Abstract)

Background: Steroid-induced hypopigmentation and lipoatrophy is common complication of corticosteroid intralesional injection (ILI). Steroid-induced atrophy is a major problem for Caucasian, but in addition to atrophy, hypopigmentation is an important problem in Asian skin. Objectives: To evaluate the clinical efficacy of normal saline (NS) and polydeoxyribonucleotide (PDRN) ILI plus 308-nm excimer laser on patients with steroid-induced hypopigmentation and lipoatrophy. Methods: Retrospective chart reviews and photographic analysis were performed for patients. NS ILI and PDRN ILI are injected at 30-45° angle for administration into dermis and upper subcutaneous tissue. Patients were divided into 3 groups: group 1 (n=3) received NS ILI plus PDRN ILI plus 308-nm excimer, group 2 (n=2) received NS ILI plus PDRN ILI and group 3 (n=1) received NS ILI. Clinical improvement was assessed by two dermatologists using a 5-point global assessment scale. Results: Six patients were analyzed. The improvement of hypopigmentation was more significantly observed in group1, which combined 308-nm excimer laser. Improvement of lipoatrophy was similarly observed in all three groups. Conclusion Combination therapy of NS ILI, PDRN ILI and 308-nm excimer laser could be effective and safe treatment choice for steroid-induced hypopigmentation and lipoatrophy. This treatment is significant in that it improved not only lipoatrophy but also hypopigmentation.