家兎 子宮, 골격근 및 心臟組織의 Catecholamine 含量과 Human Chorionic Gonadotropin 및 Chlorpromazine이 이에 미치는 影響 = An Experimental Study of the Effects of Human Chorionic Gonadotropin and Chlorpromazine Administration on the Catecholamine Content in Uterine, Skeletal Muscle and Heart Muscle Tissue of Mature Female Rabbits

다국어 초록 (Multilingual Abstract)

Chlorpromazine, one of the antihistaminic drugs, has been used for hypertensive disorders of pregnancy, the menopausal syndrome, dysmenorrhea, and pre-menstrual tension. The drug may induce a number of untoward side effects, such as dysfunction of the hypothalamic-pituitary-gonadal-uterine axis, pituitary-thyrotropic axis, and growth hormone.
An attempt was made to clarify the effects of chlorpromazine on the catecholamine contents of uterine, skeletal muscle and heart muscle tissue of mature female albino rabbits weighting approximately 2.0㎏.
A group of albino rabbits was conditioned with 50 I.U. /㎏ of hCG(human chorionic gonadotropin) for 5 days. Another group was conditioned with 25 ㎎/㎏ of chlorpromazine plus 50 I.U. /㎏ of hCG for 5 days and was observed for 24 hours.
Catecholamine content was determined by the Shore and Olin method.
The results obtained were as follows;
1. The catecholamine content in normal uterine tissue was 0.40 ㎍/gm, while that of skeletal muscle tissue was 0.11 ㎍/gm and that of heart muscle tissue 0.69 ㎍/gm. The catecholamine content in heart muscle tissue was richest; then in the uterine and in the skeletal muscle tissue, respectively.
2. In the hCG conditioned group, the catecholamine content in the uterine was 0.13 ㎍/gm, while that of skeletal muscle tissue was 0.07 ㎍/gm and that of heart muscle tissue 0.70 ㎍/gm. It also showed that catecholamine content in the heart muscle tissue was richest; then in the uterine and skeletal muscle tissue, respectively.
3. In the chlorpromazine plus hCG conditioned group, the catecholamine content in the uterine tissue was 0.15 ㎍/gm, while that of skeletal muscle tissue was 0.09 ㎍/gm and that of heart muscle was the richest among the three organs.
4. The catecholamine content of the uterine tissue showed a marked decrease in the hCG conditioned group while there was no significant change in the content of the chlorpromazine plus hCG conditioned group.
5. The catecholamine content of the skeletal muscle tissue was decreased by hCG conditioning and then increased to the level of the normal group following chlorpromazine plus hCG conditioning.
6. There was no significant change in the heart muscle tissue in the hCG conditioned group, but there was a marked decrease in the chlorpromazine plus conditioned group.
7. The catecholamine content of the uterine tissue was markedly decreased in the hCG conditioned group, while there was no significant change in the chlorpromazine plus hCG conditioned group. In the skeletal muscle tissue, the catecholamine content showed a marked decrease in the hCG conditioned group, and then increased to the level of the normal group following chlopromazine plus hCG conditioning. There was no significant change in the muscle tissue of the hCG conditioned group, but there was a marked decrease in the chlorpromazine plus hCG conditioned group.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗資料 및 方法
• 1. 實驗動物
• 2. Human Chorionic Gonadotropin 및 Chlorpromazine 投與方法과 子宮, 骨격筋 및 心臟組織의 採取方法
• 3. Catecholamine 含量의 測定方法
• Ⅲ. 實驗成績
• 1. 正常子宮, 骨격筋 및 心臟組織內 Catecholamine 含量의 比較
• 2. hCG 投與後 子宮, 骨격筋 및 心臟組織內 Catecholamine 含量의 比較
• 3. Chlorpromazine 投與後 hCG 投與時 子宮, 骨격筋 및 心臟組織內 Catecholamine 含量의 比較
• 4. 子宮組織內 Catecholamine 含量의 正常, hCG 및 Chlorpromazine 投與時의 比較
• 5. 骨격筋 組織內 Catecholamine 含量의 正常, hCG 및 Chlorpromazine 投與後의 比較
• 6. 心臟組織內 Catecholamine 含量의 正常, hCG 및 Chlorpromazine 投與後의 比較
• 7. 子宮, 骨격筋 및 心臟組織內 Catecholamine 含量의 正常, hCG 및 Chlorpromazine 投與後의 比較
• Ⅳ. 考按
• Ⅴ. 結論
• 參考文獻