체중 변화에 따른 혈청 지질의 변화 = Changes in Lipid Profile in Relation to the Change in Body Weight

다국어 초록 (Multilingual Abstract)

BackgroundHyperlipidemia is a known risk factor of coronary artery diease. To evaluate the degree of changes in lipid profile with body weight change, we analysed the changing pattern of lipid profile in relation to the change in body mass index for 2 years among those who showed no changes in life style patterns.MethodsWe gathered information on diet pattern, excercise, smoking, and drinking by questionnaire and interview. And then we selected 2,898 persons who showed no changes in their life style during 2 years(2002~2004). We assessed changes in their body mass index and lipid profile including HDL-Cholesterol, LDL-Cholesterol, Triglyceride, Lipoprotein(a), Apolipoprotein A-I, andApolipoprotein B, and performed correlation analysis.ResultsAfter 2 years of follow up, the body weight increased 1.85% in men and 0.53% in women. The lipid profile showed increasing pattern in all items checked except total cholesterol. Total cholesterol, LDL-C, TG and Apo B were positively correlated with the body weight change with  significance. HDL-C, Lp(a), Apo A-I were negatively correlated with the BMI change but did not reach statistical significance.ConclusionsOur results imply that reducing BMI to some degree also would lead to improvement in lipid profile, so it will contribute to the prevention and management of hyperlipidemia.

국문 초록 (Abstract)

연구배경관상동맥질환의 위험인자로 알려져 있는 고지혈증에 관한 연구로서, 본 연구에서는 지난 2년간 생활습관상의 변화가 없었던 사람들을 대상으로 체중변화와 혈청 지질의 관련성을 밝히고자 하였다.방 법2002년부터 2004년까지 20~80대의 다양한 연령층의 남녀 건강검진 수진자들에서 식이생활, 운동량, 흡연 및 음주와 같은 생활 습관에 대한 정보를 설문지 및 인터뷰를 통해 모은 후, 이들 생활형태의 변화가 없는 2,898명을 선정하였다. 체중은 체질량지수(BMI, Kg/m2)로 평가하였고 이들의 변화와 다양한 지질지표간의 상관분석을 시행하였다.결 과2년의 추적관찰 결과, 체중은 남자에서 1.85%, 여자에서 0.53%가 증가하였고, 지질지표는 총콜레스테롤을 제외한 모든 항목에서 증가하는 양상을 보였다. 총콜레스테롤, 저밀도지단백콜레스테롤, 중성지방 및 아포지단백 B는 통계적으로 의미있게 체중 변화와 양의 상관관계를 보였다. 고밀도지단백콜레스테롤, 지단백(a), 아포지단백 A-I은 체중변화와 음의 상관관계를 보였으나 통계적인 의미를 갖지는 못하였다.결 론체질량지수의 감소는 고지혈증의 예방 및 치료에 기여할 수 있는 지질지표상의 향상을 가져올 수 있다.

참고문헌 (Reference)

• 1 RR Wing, "Weight cycling in humans : a review of the literature" 14 : 113-119, 1992
• 2 RW Jeffery, "Weight cycling and cardiovascular risk factors in obese men and women" 55 : 641-644, 1992
• 3 TP Whitedhead, "The effects of cigarette smoking and alcohol consumption on blood lipids: a dose-related study on men" 33 : 99-106, 1996
• 4 Lipid Research Clinics Program, "The Lipid Research Clinics Coronary Primary Prevention Trial results" 251 : 364-, 1984
• 5 JH Cho, "The Levels of Serum Total Cholesterol and Triglyceride in Healthy Korean Adults" 4 (4): 182-189, 1994
• 6 HY Jeon, "The Factors associated with Serum Triglyceride Level in Healthy Adults" 29-42, 1988
• 7 JD Neaton, "Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease.Overall findings and difference by age for 316,099 white men. Multiple Risk Factor Research Group (MRFIT)" 152 : 56-64, 1992
• 8 N Nakanishi, "Relationship between lifestyle and serum lipid lipoprotein levels in middle-aged Japanese men" 15 : 341-348, 1999
• 9 FW Ashley, "Relation of weight change to changes in atherogenic traits: The Framinham Studt" 27 : 103-114, 1974
• 10 G Schuler, "Regular physical exercise and low fat diet: effects on progression of coronary artery disease" 86 : 1-11, 1992
• 11 SN Blair, "Physical fitness and all cause mortality: A prospective study of health men and women" 262 : 2401-, 1989
• 12 A Murai, "Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction" 59 : 199-204, 1986
• 13 G Uri, "Isolated Low HDL Cholesterol As a Risk Factor for Coronary Heart Disease Mortality. A 21-Year Follow-up of 8,000 Men" 17 : 1997
• 14 RN Wolf, "Influence of weight reduction on plasma lipoprotein in obese patients" 3 : 160-169, 1983
• 15 E Braunwail, "Harrison's Principles of Internal Medicine 15th edition" 2003
• 16 MC Corti, "HDL cholesterol predicts coronary heart disease mortality in order persons" 274 : 539-544, 1995
• 17 MS Suh, "Factors associated low HDL-cholesterol in adults" 22 : 1214-1223, 2001
• 18 G Walldius, "Apolipoprotein B and Apolipoprotein A-I: risk indicators of CHD and targets for lipid-modifying therapy" 255 : 188-205, 2004
• 19 RA Rein hart, "Apolipoprotein A-I and B as predictors of angiographically defined coronary artery disease" 150 : 1629-1633, 1990
• 20 SR Choudhury, "Alcohol intake and serum lipids in Japanese population" 23 : 940-947, 1994