이중층 폴리피롤 복합재료 지지체 = Polypyrrole/Poly(1-(2-carboxyehtyl)pyrrole) Bilayered Composite Scaffold for Cell Adhesion

국문 초록 (Abstract)

전도성 고분자-폴리피롤은 화학구조상 공유결합을 할수 있는 작용기가 존재하지 않는다. 이에 상용 1-(2-cyanoethyl)-pyrrole을 가수분해 반응시켜 카복실산 작용기를 갖는 피롤유도단량체를 합성하고 이를 폴리피롤의 표면상에서 전기화학적으로 고분자 중합하여, 이중층으로 구성된 전도성 복합재료 지지체를 개발하였다. 지지체 표면에 도입한 카복실산 작용기와 조직인식(Arg-Gly-Asp(RGD)를 포함하는)-올리고펩타이드를 선택적으로 화학결합시킨 후, 모델 세포조직-인간 제대혈관 내피세포(HUVEC)의 흡착 및 증식정도에 대한 정성및 정량평가를 통해 생물학적 활성이 증진됨을 확인할 수 있었다. 따라서, 이상에서 개발된 전도성 폴리피롤 복합재료는조직공학을 위한 생체모사용 지지체로서 다양한 플랫폼 역할을 할 것으로 기대된다.

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