신경세포이주장애질환을 가진 간질환자에 대한 수술 체험 = Preliminary Result of Epilepsy Surgery in Patients with Neuronal Migration Disorder

다국어 초록 (Multilingual Abstract)

Neuronal migration disorders(NMD's) are a rare group of development structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar neuronal arrangement, often causing intractable seizures.
During September 1994 to February 1995, we operated on six patients with NMD to treat intractable seizures. Male to female ratio of these 6 patients was 2 : 4, and mean age at seizure onset was 14 years old(range 6-28 years), indicating early onset of epilepsy. Mean age at seizure surgery was 29 years old(range 23-41 years), and mean follow-up duration after operation was 4 months(range 3-6 months). In their past medical history, three patients had experienced febrile seizure at pediatric age, and one of them had a history of anoxic damage during delivery. Following preoperative localization, the lesion was removed completely in five patients. In the other one patient, part of the lesion was located in the speech and motor area, leading to partial removal. On histologic examination two of them showed cortical dysplasia and the other four revealed microdysgenesis. During follow-up for six months, five patients were free of seizure and in the other one patient, whose lesion was removed incompletely, the frequency of seizure decreased by 95%.