정량적 컴퓨터 단층촬영을 이용한 골밀도 검사에 있어 정확한 측정위치에 관한 연구

다국어 초록 (Multilingual Abstract)

Purpose : In terms of the bone density examination by QCT, the study would compare the bone density value is changed based on ROI location at the thoracic vertebrae as well as the lumbar vertebrae and measurement angle at the femoral neck. With any results found from the comparison, the study shall come up with a reference point that will realize the accurate measurement of the bone density.
Object and Research Method : The study has carried out onto a patients group that consisted of 2 males and 53 females who received QCT check in the concerned hospital between November 1, 2012 and January 31, 2013. The study has selected patients who have never been diagnosed with a bone fracture at a part to be measured for the bone density in order to improve reliability of the measurement.
Regarding CT equipment used in the study, LightSpeed VCT 64 by GE was adopted while acquired data was analyzed by QCT PROTM(Mindway, GE, Madison, WI, USA) program to measure BMD(bone mineral density)(mg/cm³), Z-score and T-score of (thoratic spine 12), L-1(lumbar spine 1), L-2(lumbar spine 2) and the femoral neck.
For a control group, the measurement was operated based on the fundamental correcting criterion recommended by QCT program. For an experimental group, the correcting criterion should be identical with that of the control group but still, at the final stage, ROI location of the thoracic vertebrae and the lumbar vertebrae will not include venus complex defect. For that purpose, ROI has been moved to the center before the bone density was measured, and again, in case of the femoral neck, the study was conducted as the measurement angles were revised by 5˚ and 10˚ upwards as well as 5˚and 10˚ downwards.
Such experiments were carried out to pursue reliability of the confirmed hypothesis which says that a different bone density measurement location will affect measurement values. Out of the 55 research objects, 20 were randomly selected to be separately measured for the bone density by five radiological technologists. Afterwards, any significant differences were searched in each of the groups.
Results : When it comes to comparing the bone density of the thoracic vertebrae and the lumbar vertebrae from the control group and the experimental group, in case of BMD with ROI moved to the center, the experimental group was appeared to have BMD value of 147.8, 137.5 and 152.9 mg/cm³ for T-12, L-1 and L-2. The findings were proved to be higher by 8.5%, 4.7% and 17.7% than those of the control group. In terms of Z-score and T-score, the experimental group, again, came up with greater values by 64.6% and 26.3%.
A significance test was carried out to study a correlation depending on different ROI location. According to the results, all BMD values of the thoracic vertebrae and the lumbar vertebrae between the groups were found to have a significant difference. That went the same both with Z-score and T-score values as they came out with another significant value.
In case of the femoral neck, different angles were adopted for the experimental group. The results were compared to those values from the other parts, and BMD, T-score and Z-score of the femoral neck appeared to have a great difference with the maximum value and the minimum value. That was proved to be statistically significant with a value of p<0.05.
Five radiological technologists separately performed a clinical research on the selected patients. According to the results, all the five objects came up with a different average value with BMD, and for the gap between the maximum value and the minimum value, T-12 showed 10.7 while L-1 and L-2 ended up with 5.7 and 12.6 respectively.
As to the difference of Score with the maximum value and the minimum value, Z-score provided 0.156 while T-score showed 0.271. The three groups were confirmed to have a significant difference (p<0.05). The difference between the maximum value and the minimum value of BMD, Z-score and T-score of the femoral neck were dete