난소 과립막 세포종의 임상병리학적 특징의 고찰 = Clinicopathologic prognostic factors of granulosa cell tumor of the ovary

국문 초록 (Abstract)

-국문초록-
목적: 과립막 세포종의 임상병리학적 특징을 알아보고자 하였다.
방법: 1994년 6월부터 2006년 12월까지 본원에서 수술후 과립막세포종으로 확진된 15예를 대상으로 하였다. 모
든 환자들의 의무기록을 후향적으로 비교 검토하여 초기 증상, 나이, 종괴의 크기, FIGO 병기, 치료 방법 등을
조사하였으며, 병리학적 소견으로 유사분열지수(MI)를 조사하였다.
결과: 진단 시 중간 연령은 47세(범위는 22-78세) 이었고, FIGO 병기에 따른 환자의 분포는 병기 1기 80%
(12/15), 병기 3기 20%(3/15)로 조사되었다. 5명의 환자에서 완전한 병기 결정수술을 받았으며, 나머지 환자들
은 종양 제거술로써 전자궁 적출술 및 부속기 절제술 혹은 부속기 절제술만 시행받았다. 수술 후 6명의 환자에
서 항암화학요법이 시행되었다. 3예의 환자에서 재발이 확인되었다. 2예는 병기 3기 였으며, 1예는 병기 1기이
나 종양의 크기가 20cm로 크기가 큰 경우였다. 재발 환자의 유사분열 지수는 13, 11이었다. 8년 생존율은
62.5%였다.
결론: FIGO 병기가 III기 이상으로 높은 경우와 병기는 I기 이지만 종양의 크기가 20cm이상으로 큰 경우에 재
발을 확인하였다. 그리고, 병리 소견상 유사분열지수가 높을수록 고병기를 나타내는 것을 알 수 있었다. 향후
병기 I에서 종양의 크기나 유사분열지수가 재발을 예측할 수 있는지에 관한 다기관 연구가 필요하리라 사료된
다.

다국어 초록 (Multilingual Abstract)

-abstract- Objective: The purpose of this study was evaluate the clinicopathologic prognostic factors of granulosa cell tumors(GCTs) of the ovary. Methods: We reviewed the medical records retrospectively of 15 patients of GCT who confirmed GCT pathologically after surgery from June, 1994 to December, 2006. Initial symptom, age, size of tumors, FIGO stage, treamtment modality and mitotic index were investigated from medical records. Results: The median age of the patients were 47(range 22-78). Distribution of patients by FIGO stage were stage I 80%(12/15), stage III 20%(3/15). Complete surgical staging was performed in 5 patients. Other patients were performed total abdominal hysterectomy with bilateral or unilateral salpingo- ophorectomy, bilateral or unilateral salpingo-ophorectomy 5 patients were given adjuvant chemotherapy. Recurrence were founded in 3 patients. Two patients were FIGO sage III and one was stage I with large tumor size. The mitotic index was 13, 11 and one patients was not described about that. Eight year survial rate of all patients was 62.5%. Conclusion: There was recurrence in high FIGO stage. Mitotic index was related with FIGO stage. Mitotic index and tumor size are the probable prognostic factors and need to study the relationship with recurrence in stage I.

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