Plasma induced carbon based thin films for bioapplications
저자
발행사항
Seoul : Sungkyunkwan university, 2017
학위논문사항
Thesis (Ph.D.)-- Sungkyunkwan university : Department of Advanced Materials Science and Engineering 2017. 2
발행연도
2017
작성언어
영어
주제어
발행국(도시)
서울
형태사항
xiii, 204 p. : ill.(some col.), charts ; 30 cm
일반주기명
Adviser: JEON GEON HAN
Includes bibliographical references (p. 188-204)
DOI식별코드
소장기관
With the emergence of the new technologies and materials, regenerative medicine has been the center of attention owing to its reliability and superiority to the alternative transplantations facing the risk of cross infection as well as the shortage of supply in transplantation. Numerous materials including organic (polymers, grapheme, carbon films etc.) and inorganic (ceramic, metal oxides etc.) are used for various end uses in bioapplications. Most of the synthetic materials used for regenerative medicine face the challenge of insufficient biocompatibility. The biocompatibility and bioactivity of materials and surfaces can be enhanced by carefully tailoring the surface properties such as surface chemistry, surface energy and surface electrical conductivity.
Further, the contamination of materials and surfaces by bacteria has raised the concerns about healthcare resulting in an increase in medical cost. Most of the hospital acquired infections are caused by pathogenic bacteria contributing to the poor treatment efficacy. Thin films embedded with the metal nanoparticles (NPs) exhibit promising antibacterial activity making them the desired materials for health care applications.
In this research work, an environmental friendly, reliable and reproducible plasma processing technique has been adopted to deposit the nanoscale carbon based thin films to tailor and control the surface chemistry, surface energy and surface conductivity. The surface chemistry of polyethylene glycol like films is tailored in plasma enhanced chemical vapour deposition by the addition of nitrogen gas along with the precursor in plasma. The amine and amide functional groups, successfully induced into the chemical structure of films, increase the surface energy of the films and exhibit the significant enhancement in the growth of L 929 mouse fibroblast cells. This method, providing film deposition and functionalization simultaneously, is an excellent alternative to the post plasma treatment and biomolecule immobilization to enhance bioactivity.
Further, carbon films are synthesized through unbalanced closed field facing target magnetron sputtering technique. The film structure has been controlled by varying the power density, working pressure, addition of reactive gas and ICP power source. We found that the films are grown in columnar structure with tunable inter-columnar separation that controls the surface wettability. The inter-columnar spacing and wettability have correlation of direct proportionality to the working pressure and are correlated inversely to the power density. The higher wettability of the films supports the cell attachment through facilitating cell spreading phenomenon. The microstructure, as analyzed by Raman spectroscopy, exhibits that the higher power density and lower pressure are the most favourable conditions to synthesize the films with dominant sp2 bonding that control the electrical resistivity of the films. The elevated electron temperature plays a key role to configure the structure with dominant sp2 hybridization and higher film density. The lower electrical resistivity of the films, providing the higher stimulating interface, enhances the growth of L929 and Saos-2 cells. Further, the scope of the study has been extended by doping the carbon films with N gas and applying ICP antenna for enhanced ionization. The addition of ICP significantly increases the deposition rate (40% with N) with relatively dense structure. It is interesting to observe the promising stability of N-doped carbon films against steam sterilization (bacterial disinfection) characterized through the electron transport characteristic study and exhibit the potential of carbon films in reusable medical devices.
Further, the carbon films embedded with the Cu NPs are fabricated by co-sputtering technique. Initially, the process is optimized for minimum size of NPs by controlling the input ion energy. The volume fraction of NPs is kept constant to minimize its effect on other film properties and bioactivity. The films with smaller size NPs show Cu ion release and higher antibacterial activity. Further, the structure of the film is tailored by varying atomic% of Cu and film porosity. The films with the higher Cu atomic% and more porous structure exhibit the higher Cu ions release and maximum antibacterial activity. It is further observed that the formation of oxide layer on Cu NPs does not impair the antibacterial activity significantly.
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