Neck circumference and incidence of cerebrovascular disease over 12 years among Korean adults

다국어 초록 (Multilingual Abstract)

Objectives: Neck circumference is associated with a distinctive fat storage process that confers additional metabolic risk. Hence, this study aimed to investigate the correlation between baseline neck circumference and the incidence of cerebrovascular disease using a prospective community-based sample of Korean adults over 12 years of follow-up, after controlling for selected covariates.
Methods: Participants with non-cerebrovascular disease were divided into 4 groups (Q1–Q4) based on their baseline neck circumference. Cox proportional hazards analysis was used to calculate hazard ratios and 95% confidence intervals (CIs) to evaluate the relationship between neck circumference and cerebrovascular disease incidence over a 12-year period.
Results: Among this study’s 3,662 participants, 128 (3.50%) developed cerebrovascular disease. The incidence of cerebrovascular disease increased from 2.2% in Q1 to 4.3% in Q2, 2.5% in Q3, and 5.0% in Q4. When compared to Q1, the relative risks of cerebrovascular disease development were 0.57 (95% CI, 0.25–1.31), 0.86 (95% CI, 0.38–1.96), and 0.79 (95% CI, 0.30–2.07) in man and 1.86 (95% CI, 0.66–5.20), 3.50 (95% CI, 1.25–9.86), and 4.71 (95% CI, 1.50–14.77) in woman in Q2, Q3, and Q4, respectively, after adjusting for most risk factors related to cerebrovascular disease.
Conclusion: The relationship between neck circumference and cerebrovascular disease was stronger in woman than in man, indicating potential differences between the sexes. These results are meaningful for evaluating and surveilling neck circumference as a promising tool for identifying subgroups of vulnerable and at-risk populations.

참고문헌 (Reference)

• 1 김천식 ; 김대식, "폐쇄성 수면무호흡 증후군과 목둘레 및 체질량 지수와의 상관성 연구" 대한임상검사과학회 39 (39): 141-146, 2007
• 2 정승교, "여대생의 비만평가 방법으로서의 목둘레" 기본간호학회 12 (12): 347-353, 2005
• 3 National Health Insurance, "The older you are, the more dangerous “cerebral infarction”, and lifestyle changes are needed" National Health Insurance
• 4 Marrugat J, "The estimated incidence and case fatality rate of ischemic and hemorrhagic cerebrovascular disease in 2002 in Catalonia" 60 : 573-580, 2007
• 5 Truelsen T, "Stroke incidence and prevalence in Europe : a review of available data" 13 : 581-598, 2006
• 6 Kang JH, "Relationship of neck circumference to cardiovascular risk factors" 12 : 137-145, 2003
• 7 Ben-Noun L, "Relationship of neck circumference to cardiovascular risk factors" 11 : 226-231, 2003
• 8 Fantin F, "Relationship between neck circumference, insulin resistance and arterial stiffness in overweight and obese subjects" 24 : 1532-1540, 2017
• 9 Ben-Noun LL, "Relationship between changes in neck circumference and changes in blood pressure" 17 : 409-414, 2004
• 10 Tibana RA, "Relation of neck circumference and relative muscle strength and cardiovascular risk factors in sedentary women" 10 : 329-334, 2012
• 11 Levine JA, "Relation between chubby cheeks and visceral fat" 339 : 1946-1947, 1998
• 12 Pucciarelli G, "Quality of life, anxiety, depression and burden among stroke caregivers: a longitudinal, observational multicentre study" 74 : 1875-1887, 2018
• 13 Rosenquist KJ, "Neck circumference, carotid wall intima-media thickness, and incident stroke" 36 : e153-e154, 2013
• 14 Medeiros CA, "Neck circumference, a bedside clinical feature related to mortality of acute ischemic stroke" 57 : 559-564, 2011
• 15 Famodu OA, "Neck circumference positively relates to cardiovascular risk factors in college students" 15 : 1480-, 2018
• 16 Joshipura K, "Neck circumference may be a better alternative to standard anthropometric measures" 2016 : 6058916-, 2016
• 17 Zhou JY, "Neck circumference as an independent predictive contributor to cardio-metabolic syndrome" 12 : 76-, 2013
• 18 Ben-Noun L, "Neck circumference as a simple screening measure for identifying overweight and obese patients" 9 : 470-477, 2001
• 19 Kang JH, "Neck circumference as a simple obesity index" 11 : 142-149, 2002
• 20 Preis SR, "Neck circumference as a novel measure of cardiometabolic risk : the Framingham Heart study" 95 : 3701-3710, 2010
• 21 Liang J, "Neck circumference and prehypertension : the cardiometabolic risk in Chinese study" 33 : 275-278, 2015
• 22 Cho NH, "Neck circumference and incidence of diabetes mellitus over 10 years in the Korean Genome and Epidemiology Study(KoGES)" 5 : 18565-, 2015
• 23 Arnold TJ, "Neck and waist circumference biomarkers of cardiovascular risk in a cohort of predominantly African-American college students : a preliminary study" 114 : 107-116, 2014
• 24 Korea Institute for Health and Social Affairs, "In-depth analyzes of the third national health and nutrition examination survey: the health interview and health behavior survey part" Korea Institute for Health and Social Affairs
• 25 Cyn J, "Effects of menopause on obstructive sleep apnea" 17 : 11-15, 2010
• 26 Love S, "Cerebrovascular disease in ageing and Alzheimer’s disease" 131 : 645-658, 2016
• 27 Caprio FZ, "Cerebrovascular disease : primary and secondary stroke prevention" 103 : 295-308, 2019
• 28 Portegies ML, "Cerebrovascular disease" 138 : 239-261, 2016
• 29 Khaku AS, "Cerebrovascular disease" StatPearls Publishing
• 30 Statistics Korea, "Cause of death statistics" Statistics Korea
• 31 World Health Organization (WHO), "Cardiovascular diseases (CVDs)" WHO
• 32 Kuciene R, "Association of neck circumference and high blood pressure in children and adolescents : a case-control study" 15 : 127-, 2015