유기인제계 농약이 흰쥐의 대장점막내 점액질에 미치는 영향 = The Effect of Organophosphorus Pesticides on the Mucosubstances in the Rat Large Intestinal Mucosa
저자
조운복 (부산대학교 사범대학(해부학))
발행기관
학술지명
권호사항
발행연도
1978
작성언어
Korean
KDC
051
자료형태
학술저널
수록면
143-164(22쪽)
제공처
In order to study the effect of organophosphorus pesticides on the secretion and production of the mucosubstances in the large intestinal mucosa, histochemical studies were undertaken in respect of the influence of the oral administration of the DDVP, malathion, dipterex and EPN on the mucosubstances of the goblet cells in the rat colon and rectum, and traced the change brought by experimental method, namely, 3, 6, 12, 24 and 48 hour groups of administration, respectively. The mucosubstances were stained with alcian blue pH 1.0, alcian blue pH 2.5, alcian blue pH 1.0 - periodic acid Schiff (PAS), alcian blue pH 2.5 - periodic acid Schiff (PAS), aldehyde fuchsin pH 1.7 - alcian blue pH 2.5 and high iron diamine - alcian blue pH 2.5 methods.
The following results were obtained.
1. It was contained large amounts of strong sulfated acid mucins and neutral mucins in the surface and upper-crypt goblet cells of the normal rat colon and rectum, but were seen mixed with most goblet cells were contained only large amounts of strong sulfated acid mucins and some were contained small amounts of nonsulfated acid mucins and neutral mucins in the lower-crypt goblet cells.
2. In administrated groups of pesticides, amounts of mucosubstances in the colic mucosa were remarkably diminished from 3hr after administration, and so were more remarkably diminished the surface and lower-crypt goblet cells than the upper-crypt goblet cells.
The diminution of neutral mucins were very remarked in 3 to 6hr after dipterex and EPN administration or 6 to 12hr after DDVP and malathion administration. Amounts of neutral mucins in diminution were gradually recovered thereafter 24 to 48hr after all pesticides administration.
The diminution of acid mucins were very remarked in 3 to 6hr after DDVP and EPN administration or 6 to 12hr a after malathion and dipterex administration. Amounts of acid mucins in diminution were gradually recovered thereafter 24hr after DDVP and dipterex administration or 48hr after malathion and EPN administration. Amounts of sulfated acid mucins were decreased in 3 to 12hr after administration, thereafter those were gradually increased in 24 and 48hr after administration, but amounts of nonsulfated acid mucins were some decreased in 6 to 12hr after administration, thereafter those were gradually decreased in 24 and 48hr after administration.
3. In administrated groups of pesticides, amounts of mucosubstances in the rectal mucosa were remarkably diminished from 3hr after administration, and so were more remarkably diminished the surface and lower-crypt goblet cells than the upper-crypt goblet cells.
The diminution of neutral mucins were very remarked in 3 to 6hr after DDVP and EPN administration or 6 to 12hr after malathion and dipterex administration. Amounts of neutral mucins in diminution were gradually recovered thereafter 12hr after DDVP, malathion and EPN administration or 24hr after dipterex administration.
The diminution of acid mucins were very remarked in 6hr after DDVP, malathion and EPN administration or 12hr after dipterex administration. Amounts of acid mucins in diminution were gradually recovered 12 to 24hr after DDVP and malathion dministration or 48hr after dipterex and EPN administration. Amounts of sulfated acid mucins were decreased in 3 to 6hr or 12hr after administration, thereafter those were gradually increased in 12 and 24hr after administration, but amounts of nonsulfated acid mucins were some decreased from 3hr after administration, thereafter those were gradually increased in 24 or 48hr after administration.
On the basis of the above results, it was suggested that were severely inhibited to production and secretion of mucosubstances from earlier period after organophosphorus pesticides administration, furthermore those pesticides were more severely inhibited to production of acid mucins than neutral mucins, and so were inhibited to metabolism of sulfated ester in acid mucin, in the alteration of these mucosubstances.
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