The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management

다국어 초록 (Multilingual Abstract)

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part of patient blood management (PBM) which is an important concept in improving patient safety. Here, ROTEM testing and hemostatic interventions should be linked by evidence-based, setting-specific algorithms adapted to the specific patient population of the hospitals and the local availability of hemostatic interventions. Accordingly, ROTEM-guided algorithms implement the concept of personalized or precision medicine in perioperative bleeding management (‘theranostic’ approach). ROTEM-guided PBM has been shown to be effective in reducing bleeding, transfusion requirements, complication rates, and health care costs. Accordingly, several randomized-controlled trials, meta-analyses, and health technology assessments provided evidence that using ROTEM-guided algorithms in bleeding patients resulted in improved patient’s safety and outcomes including perioperative morbidity and mortality. However, the implementation of ROTEM in the PBM concept requires adequate technical and interpretation training, education and logistics, as well as interdisciplinary communication and collaboration.

참고문헌 (Reference)

• 1 Rossetto V, "Whole blood rotation thromboelastometry(ROTEMⓇ)profiles in subjects with non-neoplastic portal vein thrombosis" 132 : e131-e134, 2013
• 2 Collins PW, "Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage : OBS2, an observational study" 119 : 422-434, 2017
• 3 Collins PW, "Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage : OBS2, a double-blind randomized controlled trial" 119 : 411-421, 2017
• 4 Whiting P, "Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis : a systematic review and cost-effectiveness analysis" 19 : 1-228, 2015
• 5 Harr JN, "Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early" 41 : 49-56, 2015
• 6 Mace H, "Validity of thromboelastometry for rapid assessment of fibrinogen levels in heparinized samples during cardiac surgery : a retrospective, single-center, observational study" 30 : 90-95, 2016
• 7 Ortmann E, "Validation of viscoelastic coagulation tests during cardiopulmonary bypass" 13 : 1207-1216, 2015
• 8 Gronchi F, "Validation of rotational thromboelastometry during cardiopulmonary bypass : A prospective, observational in-vivo study" 31 : 68-75, 2014
• 9 Guan J, "Utility of intraoperative rotational thromboelastometry in thoracolumbar deformity surgery" 27 : 528-533, 2017
• 10 Debernardi Venon W, "Usefulness of thromboelastometry in predicting the risk of bleeding in cirrhotics who undergo invasive procedures" 27 : 1313-1319, 2015
• 11 Toffaletti JG, "Use of earlier-reported rotational thromboelastometry parameters to evaluate clotting status, fibrinogen, and platelet activities in postpartum hemorrhage compared to surgery and intensive care patients" 128 : 414-423, 2019
• 12 Maegele M., "Uncritical use of tranexamic acid in trauma patients : Do no further harm!" 119 : 967-972, 2016
• 13 Brohi K, "Traumatic coagulopathy and massive transfusion : improving outcomes and saving blood" 5 : 1-73, 2017
• 14 Nardi G, "Trauma-induced coagulopathy : impact of the early coagulation support protocol on blood product consumption, mortality and costs" 19 : 83-, 2015
• 15 Görlinger K, "Trauma Induced Coagulopathy" Springer Nature Switzerland AG 267-298, 2016
• 16 Smith NK, "Transfusion-related acute lung injury(TRALI)and transfusion-associated circulatory overload(TACO)in liver transplantation : a case report and focused review" 22 : 180-190, 2018
• 17 Holcomb JB, "Transfusion of plasma, platelets, and red blood cells in a 1 : 1 : 1 vs a 1 : 1 : 2 ratio and mortality in patients with severe trauma : the PROPPR randomized clinical trial" 313 : 471-482, 2015
• 18 Fries D, "Transfusion approaches and mortality in trauma patients : a narrativereview" 43 : 759-771, 2017
• 19 Butwick AJ, "Transfusion and coagulation management in major obstetric hemorrhage" 28 : 275-284, 2015
• 20 Moore HB, "Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis" 220 : 438-443, 2017
• 21 Nakayama Y, "Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery" 114 : 91-102, 2015
• 22 Oswald E, "Thromboelastometry(ROTEM)in children : age-related reference ranges and correlations with standard coagulation tests" 105 : 827-835, 2010
• 23 Zanetto A, "Thromboelastometry hypercoagulable profiles and portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma" 49 : 440-445, 2017
• 24 Vasques F, "Thromboelastometry guided fibrinogen replacement therapy in cardiac surgery : a retrospective observational study" 31 : 286-290, 2017
• 25 Wikkelsø A, "Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding" 8 : CD007871-, 2016
• 26 Fayed NA, "Therapeutic rather than prophylactic platelet transfusion policy for severe thrombocytopenia during liver transplantation" 25 : 576-586, 2014
• 27 Collins PW, "Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate" 113 : 585-595, 2014
• 28 Holley AD, "The ‘procoagulopathy’ of trauma : too much, too late" 19 : 578-586, 2013
• 29 Reinhöfer M, "The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass" 19 : 212-219, 2008
• 30 Curry NS, "The use of viscoelastic haemostatic assays in the management of major bleeding : a British Society for Haematology Guidelin" 182 : 789-806, 2018
• 31 Corredor C, "The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery : a systematic review and meta-analysis" 70 : 715-731, 2015
• 32 Dhillon NK, "The risk factors of venous thromboembolism in massively transfused patients" 222 : 115-121, 2018
• 33 Karkouti K, "The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery : an observational study" 117 : 14-22, 2013
• 34 CRASH-2 collaborators, "The importance of early treatment with tranexamic acid in bleeding trauma patients : an exploratory analysis of the CRASH-2 randomised controlled trial" 377 : 1096-1101, 2011
• 35 Harvin JA, "The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis" 78 : 905-909, 2015
• 36 Flisberg P1, "The effects of platelet transfusions evaluated using rotational thromboelastometry" 108 : 1430-1432, 2009
• 37 Katori N, "The effects of platelet count on clot retraction and tissue plasminogen activator-induced fibrinolysis on thrombelastography" 100 : 1781-1785, 2005
• 38 Ranucci M, "The effectiveness of 10 years of interventions to control postoperative bleeding in adult cardiac surgery" 24 : 196-202, 2017
• 39 Kander T, "The effect and duration of prophylactic platelet transfusions before insertion of a central venous catheter in patients with bone marrow failure evaluated with point-of-care methods and flow cytometry" 119 : 882-890, 2014
• 40 Charbit B, "The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage" 5 : 266-273, 2007
• 41 Tripodi A, "The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters" 124 : 132-136, 2009
• 42 Rossaint R, "The European guideline on management of major bleeding and coagulopathy following trauma : fourth edition" 20 : 100-, 2016
• 43 Moore HB, "Targeting resuscitation to normalization of coagulating status : Hyper and hypocoagulability after severe injury are both associated with increased mortality" 214 : 1041-1045, 2017
• 44 Winearls J, "Targeted coagulation management in severe trauma : the controversiesand the evidence" 123 : 910-924, 2016
• 45 Smith I, "Targeted bleeding management reduces the requirements for bloodcomponent therapy in lung transplant recipients" 31 : 426-433, 2017
• 46 Dunham CM, "TEGⓇ and RapidTEGⓇ are unreliable for detecting warfarincoagulopathy : a prospective cohort study" 12 : 4-, 2014
• 47 European Commission, Directorate-General for Health and Food Safety, "Supporting patient blood management (PBM) in the EU. A practical implementation guide for hospitals" Publications office of the European Union
• 48 Dallaku K, "Statistical analysis plan for the WOMAN-ETAPlaT study : effect of tranexamic acid on platelet function and thrombin generation" 1 : 30-, 2016
• 49 Hanke AA, "Spinal anaesthesia and caesarean section in a patient with hypofibrinogenaemia and factor XIII deficiency" 65 : 641-645, 2010
• 50 Bolton-Maggs PH, "Serious Hazards of Transfusion(SHOT)haemovigilance and progress is improving transfusion safety" 163 : 303-314, 2013
• 51 Bouillon B für die Deutsche Gesellschaft für Unfallchirurgie, "S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung"
• 52 Naik BI, "Rotational thromboelastometry-guided blood product management in major spine surgery" 23 : 239-249, 2015
• 53 Prat NJ, "Rotational thromboelastometry significantly optimizes transfusion practices for damage control resuscitation in combat casualties" 83 : 373-380, 2017
• 54 Hincker A, "Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery" 18 : 549-, 2014
• 55 Smart L, "Rotational thromboelastometry or conventional coagulation tests in liver transplantation: comparing blood loss, transfusions, and cost" 16 : 916-923, 2017
• 56 Bedreli S, "Rotational thromboelastometry can detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis" 37 : 562-568, 2017
• 57 Christoph Raspé, "Rotational Thromboelastometry for Assessing Bleeding Complications and Factor XIII Deficiency in Cardiac Surgery Patients" SAGE Publications 24 (24): 136S-144S, 2018
• 58 Clifford L, "Risk factors and clinical outcomes associated with perioperativetransfusion-associated circulatory overload" 126 : 409-418, 2017
• 59 Innerhofer P, "Reversal of trauma-induced coagulopathy using firstline coagulation factor concentrates or fresh frozen plasma(RETIC) : a single-centre, parallel-group, open-label, randomised trial" 4 : e258-e271, 2017
• 60 Wang J, "Restrictive vs liberal transfusion for upper gastrointestinal bleeding : a meta-analysis of randomized controlled trials" 19 : 6919-6927, 2013
• 61 Blasi A, "Reliability of thromboelastometry for detecting the safe coagulation threshold in patients taking acenocoumarol after elective heart valve replacement" 136 : 669-672, 2015
• 62 Faraoni D, "Relationship between transfusion of blood products and the incidence of thrombotic complications in neonates and infants undergoing cardiacsurgery" 31 : 1943-1948, 2017
• 63 Oudghiri M, "Reference values for rotation thromboelastometry (ROTEMⓇ) parameters following non-haemorrhagic deliveries. Correlations with standard haemostasis parameters" 106 : 176-178, 2011
• 64 Sokou R, "Reference ranges of thromboelastometry in healthy full-term and pre-term neonates" 55 : 1592-1597, 2017
• 65 Görlinger K, "Reduction of fresh frozen plasma requirements by perioperative point-of-care coagulation management with early calculated goal-directed therapy" 39 : 104-113, 2012
• 66 Abuelkasem E, "Reduced requirement for prothrombin complex concentrate for the restoration of thrombin generation in plasma from liver transplantrecipients" 125 : 609-615, 2017
• 67 Stettler GR, "Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays" 86 : 679-685, 2019
• 68 Simpson E, "Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia" 3 : CD005011-, 2012
• 69 Ichikawa J, "Reappearance of circulating heparin in whole blood heparin concentration-based management does not correlate with postoperative bleeding after cardiac surgery" 28 : 1003-1007, 2014
• 70 Moore EE, "Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient" 56 (56): S110-S114, 2016
• 71 Olde Engberink RH, "Rapid and correct prediction of thrombocytopenia and hypofibrinogenemia with rotational thromboelastometry in cardiac surgery" 28 : 210-216, 2014
• 72 Ranucci M, "Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery" 4 : e002066-, 2015
• 73 Pearse BL, "Protocol guided bleeding management improves cardiac surgery patient outcomes" 109 : 267-279, 2015
• 74 Grottke O, "Prothrombin complex concentrates in trauma and perioperative bleeding" 122 : 923-931, 2015
• 75 Gouvêa G, "Protamine sulphate for treatment of severe post-reperfusion coagulopathy in pediatric liver transplantation" 13 : 1053-1057, 2009
• 76 Ni Ainle F, "Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation" 114 : 1658-1665, 2009
• 77 Koster A, "Protamine overdose and its impact on coagulation, bleeding, and transfusions after cardiopulmonary bypass : results of a randomized double-blind controlled pilot study" 20 : 290-295, 2014
• 78 Warner MA, "Prophylactic plasma transfusion is not associated with decreased red blood cell requirements in critically Ill patients" 124 : 1636-1643, 2017
• 79 Yamamoto T, "Prolonged activated clotting time after protamine administration does not indicate residual heparinization after cardiopulmonary bypass in pediatric open heart surgery" 63 : 397-403, 2015
• 80 Hagemo JS, "Prevalence, predictors and outcome of hypofibrinogenaemia in trauma : a multicentre observational study" 18 : R52-, 2014
• 81 Fayed N, "Preoperative thromboelastometry as a predictor of transfusion requirements during adult living donor liver transplantation" 42 : 99-108, 2015
• 82 Warner MA, "Preoperative platelet transfusions and perioperative red blood cell requirements in patients with thrombocytopenia undergoing noncardiac surgery" 56 : 682-690, 2016
• 83 Blasi A, "Prediction of thromboembolic complications after liver resection for cholangiocarcinoma : is there a place for thromboelastometry" 29 : 61-66, 2018
• 84 Karon BS, "Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy" 60 : 1524-1531, 2014
• 85 Wikkelsø AJ, "Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage : randomized controlled trial" 114 : 623-633, 2015
• 86 American Society of Anesthesiologists Task Force on Perioperative Blood Management, "Practice guidelines for perioperative blood management : an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management*" 122 : 241-275, 2015
• 87 James AH, "Postpartum hemorrhage: when uterotonics and sutures fail" 87 (87): S16-S22, 2012
• 88 Lockhart E, "Postpartum hemorrhage : a continuing challenge" 2015 : 132-137, 2015
• 89 Stéphanie Roullet, "Position of the French Working Group on Perioperative Haemostasis (GIHP) on viscoelastic tests: What role for which indication in bleeding situations?" Elsevier BV 38 (38): 539-548, 2018
• 90 Trevisan D1, "Point-of-care-based protocol with first-line therapy with coagulation factor concentrates is associated with decrease allogenic blood transfusion and costs in cardiovascular surgery : an Italian single-center experience" 82 : 1077-1088, 2016
• 91 Snegovskikh D, "Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage" 44 : 50-56, 2018
• 92 Toulon P, "Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery. A multicenter study" 101 : 394-401, 2009
• 93 Deppe AC, "Point-of-care thromboelastography/thromboelastometrybased coagulation management in cardiac surgery : a meta-analysis of 8332 patients" 203 : 424-433, 2016
• 94 Weber CF, "Point-of-care testing : a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients" 117 : 531-547, 2012
• 95 Karkouti K, "Point-of-care hemostatic testing in cardiac surgery : a stepped-wedgeclustered randomized controlled trial" 134 : 1152-1162, 2016
• 96 Leon-Justel A, "Point-of-care haemostasis monitoring during liver transplantation reduces transfusion requirements and improves patient outcome" 446 : 277-283, 2015
• 97 Ortmann E, "Point-of-care assessment of hypothermia and protamine induced platelet dysfunction with multiple electrode aggregometry(MultiplateⓇ)in patients undergoing cardiopulmonary bypass" 116 : 533-540, 2013
• 98 Vulliamy P, "Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage" 83 : 388-397, 2017
• 99 Baharoglu MI, "Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy(PATCH) : a randomised, open-label, phase 3 trial" 387 : 2605-2613, 2016
• 100 Pereboom IT, "Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury" 108 : 1083-1091, 2009
• 101 Polzin A, "Platelet reactivity in patients on aspirin and clopidogrel therapy measured by a new bedside whole-blood assay" 73 : 40-47, 2019
• 102 Mahla E, "Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery : the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG(TARGET-CABG)study" 5 : 261-269, 2012
• 103 Solomon C, "Platelet function following trauma. A multiple electrode aggregometry study" 106 : 322-330, 2011
• 104 Basili S, "Platelet count does not predict bleeding in cirrhotic patients : results from the pro-liver study" 113 : 368-375, 2018
• 105 Romlin BS, "Platelet count and function in paediatric cardiac surgery : a prospective observational study" 113 : 847-854, 2014
• 106 Meizoso JP, "Persistent fibrinolysis shutdown is associated with increased mortality in severely injured trauma patients" 224 : 575-582, 2017
• 107 Schlembach D, "Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No. 015/063, March 2016)" 78 : 382-399, 2018
• 108 Schaden E, "Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements" 109 : 376-381, 2012
• 109 Kamel Y, "Perioperative thromboelastometry for adult living donor liver transplant recipients with a tendency to hypercoagulability : a prospective observational cohort study" 45 : 404-412, 2018
• 110 Romlin BS, "Perioperative monitoring of platelet function in paediatric cardiac surgery by thromboelastometry, or platelet aggregometry" 116 : 822-828, 2016
• 111 Yassen K, "Perioperative heparinase rotational thromboelastometry monitoring during and after adult living related liver transplantation" 35 (35): 286-, 2018
• 112 Görlinger K, "Perioperative coagulation management and control of platelet transfusion by point-of-care platelet function analysis" 34 : 396-411, 2007
• 113 Görlinger K, "Perioperative Hemostasis. Coagulation for Anesthesiologists" Springer Publishing 421-445, 2015
• 114 de Lange NM, "Peri-partum reference ranges for ROTEM(R)thromboelastometry" 112 : 852-859, 2014
• 115 Meybohm P, "Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient’s outcome : a prospective, multicenter cohort study with a noninferiority design" 264 : 203-211, 2016
• 116 Zacharowski K, "Patient blood management equals patient safety" 30 : 159-169, 2016
• 117 National Blood Authority Australia, "PBM guidelines: module 1-6. 2011-2018"
• 118 Bochicchio GV, "Outcome analysis of blood product transfusion in trauma patients : a prospective, risk-adjusted study" 32 : 2185-2189, 2008
• 119 McQuilten ZK, "Optimal dose, timing and ratio of blood products in massive transfusion : results from a systematic review" 32 : 6-15, 2018
• 120 Tanaka KA, "Novel approaches in management of perioperative coagulopathy" 27 : 72-80, 2014
• 121 Schofield N, "No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin" 20 : 584-590, 2014
• 122 Girard T, "New approaches to obstetric hemorrhage : the postpartum hemorrhage consensus algorithm" 27 : 267-274, 2014
• 123 National Blood Authority Australia, "National blood management implementation strategy 2017-2021. Better management of patients’ blood … better patient outcomes"
• 124 Ranucci M, "Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines" 91 : 123-129, 2011
• 125 Althoff FC, "Multimodal patient blood management program based on a three-pillarstrategy : a systematic review and meta-analysis" 269 : 794-804, 2019
• 126 Lang T, "Multi-centre investigation on reference ranges for ROTEM thromboelastometry" 16 : 301-310, 2005
• 127 Turan A, "Morbidity and mortality after massive transfusion in patients undergoing non-cardiac surgery" 60 : 761-770, 2013
• 128 Saner FH, "Monitoring and treatment of coagulation disorders in end-stage liver disease" 32 : 241-248, 2016
• 129 Abir G, "Maternal mortality and the role of the obstetric anesthesiologist" 31 : 91-105, 2017
• 130 Wanderer JP, "Massive transfusion protocols: when to turn on, and off, the fire hose" 125 : 1827-, 2017
• 131 Kozek-Langenecker SA, "Management of severe perioperative bleeding : guidelines from the European Society of Anaesthesiology : first update 2016" 34 : 332-395, 2017
• 132 Collins PW, "Management of postpartum haemorrhage : from research into practice, a narrative review of the literature and the Cardiff experience" 37 : 106-117, 2019
• 133 Görlinger K, "Management of hemorrhage in cardiothoracic surgery" 27 (27): S20-S34, 2013
• 134 Collins P, "Management of coagulopathy associated with postpartum hemorrhage : guidance from the SSC of the ISTH" 14 : 205-210, 2016
• 135 Bedreli S, "Management of acute-on-chronic liver failure : rotational thromboelastometry may reduce substitution of coagulation factors in liver cirrhosis" 65 : 357-358, 2016
• 136 Görlinger K, "Management of Bleeding Patients" Springer Nature Switzerland AG 37-64, 2016
• 137 Görlinger K, "Management of Bleeding Patients" Springer Nature Switzerland AG 263-280, 2016
• 138 Ranucci M, "Major bleeding, transfusions, and anemia : the deadly triad of cardiac surgery" 96 : 478-485, 2013
• 139 Hanke AA, "Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate(Beriplex P/N) : a pharmacovigilance study" 110 : 764-772, 2013
• 140 Smith RA, "Lessons from four years’ experience in the use of ROTEM-guided fibrinogen concentrate in major obstetric haemorrhage" 31 (31): S7-, 2017
• 141 Alamo JM, "Is"intra-operating room"thromboelastometry useful in liver transplantation? A case-control study in 303 patients" 45 : 3637-3639, 2013
• 142 Noval-Padillo JA, "Introduction of fibrinogen in the treatment of hemostatic disorders during orthotopic liver transplantation : implications in the use of allogenic blood" 42 : 2973-2974, 2010
• 143 Mallaiah S, "Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage" 70 : 166-175, 2015
• 144 Pandey CK, "Intraoperative blood loss in orthotopic liver transplantation : The predictive factors" 7 : 86-93, 2015
• 145 Foster JC, "Initiation and termination of massive transfusion protocols : current strategies and future prospects" 125 : 2045-2055, 2017
• 146 Refaai MA, "Increased risk of volume overload with plasma compared with fourfactor prothrombin complex concentrate for urgent vitamin K antagonist reversal" 55 : 2722-2729, 2015
• 147 Meizoso JP, "Increased risk of fibrinolysis shutdown among severely injured trauma patients receiving tranexamic acid" 84 : 426-432, 2018
• 148 Smith RA, "Improved outcomes with ROTEM-guided fibrinogen concentrate in major obstetric haemorrhage" 31 (31): S14-, 2017
• 149 Leahy MF, "Improved outcomes and reduced costs associated with a health-system-wide patient blood management program : a retrospective observational study in four major adult tertiary-care hospitals" 57 : 1347-1358, 2017
• 150 Görlinger K, "Implementation of thromboelastometry-guided patient blood management results in cost-savings for blood product acquisition and potentially preventable hospital acquired complications" 228-229, 2018
• 151 Sabate A, "Impact of preemptive fibrinogen concentrate on transfusion requirements in liver transplantation : a multicenter, randomized, double-blind, placebo-controlled trial" 16 : 2421-2429, 2016
• 152 Inaba K, "Impact of plasma transfusion in trauma patients who do not require massive transfusion" 210 : 957-965, 2010
• 153 Collins NF, "Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism" 22 : 71-76, 2013
• 154 McDonnell NJ, "How to replace fibrinogen in postpartum haemorrhage situations?(Hint : Don’t use FFP!)" 33 : 4-7, 2018
• 155 Haas T, "Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery : A prospective randomised controlled trial" 115 : 234-243, 2015
• 156 Cannon JW, "High ratio plasma resuscitation does not improve survival in pediatric trauma patients" 83 : 211-217, 2017
• 157 Senzolo M, "Heparin-like effect contributes to the coagulopathy in patients with acute liver failure undergoing liver transplantation" 29 : 754-759, 2009
• 158 Khan S, "Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage" 76 : 561-567, 2014
• 159 Solomon C, "Haemostatic monitoring during postpartum haemorrhage and implications for management" 109 : 851-863, 2012
• 160 Roberts I, "Haematological and fibrinolytic status of Nigerian women with postpartum haemorrhage" 18 : 143-, 2018
• 161 Tripodi A, "Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion" 33 : 362-367, 2013
• 162 Davenport R, "Functional definition and characterization of acute traumatic coagulopathy" 39 : 2652-2658, 2011
• 163 Gonzalez EA, "Fresh frozen plasma should be given earlier to patients requiring massive transfusion" 62 : 112-119, 2007
• 164 Desborough M, "Fresh frozen plasma for cardiovascular surgery" 7 : CD007614-, 2015
• 165 Song JG, "Five-minute parameter of thromboelastometry is sufficient to detect thrombocytopenia and hypofibrinogenaemia in patients undergoing liver transplantation" 112 : 290-297, 2014
• 166 Görlinger K, "First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery : a retrospective, single-center cohort study" 115 : 1179-1191, 2011
• 167 Roberts I, "Fibrinolytic shutdown: fascinating theory but randomized controlled trial data are needed" 56 (56): S115-S118, 2016
• 168 Shimauchi T, "Fibrinolysis in living donor liver transplantation recipients evaluated using thromboelastometry : impact on mortality" 49 : 2117-2121, 2017
• 169 Chapman MP, "Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy" 75 : 961-967, 2013
• 170 Poon KS, "Fibrinolysis after reperfusion of liver graft" 53 : 41-43, 2015
• 171 Ranucci M, "Fibrinogen supplementation after cardiac surgery : insights from the Zero-Plasma trial(ZEPLAST)" 116 : 618-623, 2016
• 172 Ranucci M, "Fibrinogen levels compensation of thrombocytopenia-induced bleeding following cardiac surgery" 249 : 96-100, 2017
• 173 Ranucci M, "Fibrinogen levels after cardiac surgical procedures : association with postoperative bleeding, trigger values, and target values" 102 : 78-85, 2016
• 174 Fenger-Eriksen C, "Fibrinogen estimates are influenced by methods of measurement and hemodilution with colloid plasma expanders" 50 : 2571-2576, 2010
• 175 Collins PW, "Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage : a prospective study" 124 : 1727-1736, 2014
• 176 Görlinger K, "Fast interpretation of thromboelastometry in non-cardiac surgery : reliability in patients with hypo-, normo-, and hypercoagulability" 110 : 222-230, 2013
• 177 Na HS, "FIBTEM provides prediction of massive bleeding in total hip replacement arthroplasty" 27 : 340-346, 2016
• 178 Schöchl H, "FIBTEM provides early prediction of massive transfusion in trauma" 15 : R265-, 2011
• 179 Abuelkasem E, "Ex vivo evaluation of 4 different viscoelastic assays for detecting moderate to severe coagulopathy during liver transplantation" 22 : 468-475, 2016
• 180 Kim EH, "Evaluation of"flat-line"thromboelastography after reperfusion during liver transplantation" 47 : 457-459, 2015
• 181 Johnston LR, "Evaluation of military use of tranexamic acid and associated thromboembolicevents" 153 : 169-175, 2018
• 182 Karkouti K, "Evaluation of a novel transfusion algorithm employing pointof-care coagulation assays in cardiac surgery : a retrospective cohort study with interrupted time-series analysis" 122 : 560-570, 2015
• 183 Fuller RL, "Estimating the costs of potentially preventable hospital acquired complications" 30 : 17-32, 2009
• 184 Ostrowski SR, "Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy" 73 : 60-66, 2012
• 185 Kettner SC, "Endogenous heparin-like substances significantly impair coagulation in patients undergoing orthotopic liver transplantation" 86 : 691-695, 1998
• 186 Lodge JP, "Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation" 11 : 973-979, 2005
• 187 Sarode R, "Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding : a randomized, plasma-controlled, phase IIIb study" 128 : 1234-1243, 2013
• 188 CRASH-2 trial collaborators, "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage(CRASH-2) : a randomised, placebo-controlled trial" 376 : 23-32, 2010
• 189 Gayet-Ageron A, "Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage : a meta-analysis of individual patient-level data from 40 138 bleeding patients" 391 : 125-132, 2018
• 190 Ranucci M, "Effect of preoperative P2Y12 and thrombin platelet receptor inhibition on bleeding after cardiac surgery" 113 : 970-976, 2014
• 191 Meesters MI, "Effect of high or low protamine dosing on postoperative bleeding following heparin anticoagulation in cardiac surgery. A randomised clinical trial" 116 : 251-261, 2016
• 192 WOMAN Trial Collaborators, "Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage(WOMAN) : an international, randomised, double-blind, placebo-controlled trial" 389 : 2105-2116, 2017
• 193 Perez-Ferrer A, "Early thromboelastometry variables predict maximum clot firmness in children undergoing cardiac and non-cardiac surgery" 115 : 896-902, 2015
• 194 Dirkmann D, "Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery : a step towards earlier decision making" 57 : 594-603, 2013
• 195 Chapman MP, "Early TRAP pathway platelet inhibition predicts coagulopathic hemorrhage in trauma" 43 (43): 33-, 2015
• 196 Scharf RE, "Drugs that affect platelet function" 38 : 865-883, 2012
• 197 Valle EJ, "Do all trauma patients benefit from tranexamic acid" 76 : 1373-1378, 2014
• 198 Petricevic M, "Development of a concept for a personalized approach in the perioperative antiplatelet therapy administration/discontinuation management based on multiple electrode aggregometry in patients undergoing coronary artery surgery" 40 : 383-391, 2015
• 199 Mittermayr M, "Detection of protamine and heparin after termination of cardiopulmonary bypass by thrombelastometry(ROTEM) : results of a pilot study" 108 : 743-750, 2009
• 200 Schmidt DE, "Detection of elevated INR by thromboelastometry and thromboelastography in warfarin treated patients and healthy controls" 135 : 1007-1011, 2015
• 201 Hagemo JS, "Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry : an international prospective validation study" 19 : 97-, 2015
• 202 Ruseckaite R, "Descriptive characteristics and in-hospital mortality of critically bleeding patients requiring massive transfusion : results from the Australian and New Zealand Massive Transfusion Registry" 112 : 240-248, 2017
• 203 Kjersti Baksaas-Aasen, "Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage" Ovid Technologies (Wolters Kluwer Health) 270 (270): 1178-1185, 2018
• 204 Khan S, "Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage" 41 : 239-247, 2015
• 205 Ahn Y, "Critical Care Handbook of the General Massachusetts Hospital" Lippincott Williams and Wilkins 322-350, 2016
• 206 Abuelkasem E, "Comparison between thrombelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation" 116 : 507-512, 2016
• 207 Balvers K, "Combined effect of therapeutic strategies for bleeding injury on early survival, transfusion needs and correction of coagulopathy" 104 : 222-229, 2017
• 208 McNamara H, "Coagulopathy and placental abruption : changing management with ROTEMguided fibrinogen concentrate therapy" 24 : 174-179, 2015
• 209 Maegele M, "Coagulopathy and haemorrhagic progression in traumatic brain injury : advances in mechanisms, diagnosis, and management" 16 : 630-647, 2017
• 210 Collis R, "Coagulation point-of-care testing on the labour ward should be mandatory" 27 : 66-69, 2016
• 211 Kirchner C, "Coagulation management with factor concentrates in liver transplantation : a single-center experience" 54 : 2760-2768, 2014
• 212 Görlinger K., "Coagulation management during liver transplantation" 26 (26): S64-S76, 2006
• 213 Grottke O, "Coagulation factor concentrates and point-of-care coagulation monitoring : both might be essential for optimal treatment of trauma-induced coagulopathy" 4 : e246-e247, 2017
• 214 Caldwell SH, "Coagulation disorders and bleeding in liver disease : future directions" 13 : 155-157, 2009
• 215 Tripodi A, "Changing concepts of cirrhotic coagulopathy" 112 : 274-281, 2017
• 216 Stein P, "Change of transfusion and treatment paradigm in major trauma patients" 72 : 1317-1326, 2017
• 217 Davenport RA, "Cause of trauma-induced coagulopathy" 29 : 212-219, 2016
• 218 Kaufner L, "Can prepartum thromboelastometryderived parameters and fibrinogen levels really predict postpartum hemorrhage" 45 : 427-435, 2017
• 219 European Commission, Directorate-General for Health and Food Safety, "Building national programmes of patient blood management (PBM). A guide for health authorities" Publications office of the European Union
• 220 Petricevic M, "Bleeding risk assessment in patients undergoing elective cardiac surgery using ROTEM(Ⓡ)platelet and Multiplate(Ⓡ)impedance aggregometry" 71 : 636-647, 2016
• 221 Zamper RP, "Association between viscoelastic tests-guided therapy with synthetic factor concentrates and allogenic blood transfusion in liver transplantation : a before-after study" 18 : 198-, 2018
• 222 Dötsch TM, "Assessment of standard laboratory tests and rotational thromboelastometry for the prediction of postoperative bleeding in liver transplantation" 119 : 402-410, 2017
• 223 Sabate A, "Assessment of rotational thromboelastometry for the prediction of red blood cell requirements in orthotopic liver transplantation" 84 : 447-454, 2018
• 224 Dirkmann D, "Assessment of early thromboelastometric variables from extrinsically activated assays with and without aprotinin for rapid detection of fibrinolysis" 119 : 533-542, 2014
• 225 Gertler R, "Are the point-of-care diagnostics MULTIPLATE and ROTEM valid in the setting of high concentrations of heparin and its reversal with protamine" 25 : 981-986, 2011
• 226 Truong HT, "Anaphylaxis-induced hyperfibrinolysis in pregnancy" 24 : 180-184, 2015
• 227 Blasi A, "An assessment of thromboelastometry to monitor blood coagulation and guide transfusion support in liver transplantation" 52 : 1989-1998, 2012
• 228 Chen CH, "Amniotic fluid embolism complicated with pulmonary embolism during cesarean section : management with TEE and ROTEMⓇ" 55 : 93-94, 2017
• 229 Mallett SV, "Alterations in coagulation following major liver resection" 71 : 657-668, 2016
• 230 Annecke T, "Algorithm-based coagulation management of catastrophic amniotic fluid embolism" 21 : 95-100, 2010
• 231 Frith D, "Acute traumatic coagulopathy" 25 : 229-234, 2012
• 232 Klein AA, "AAGBI guidelines : the use of blood components and their alternatives 2016" 71 : 829-842, 2016
• 233 Veigas PV, "A systematic review on the rotational thrombelastometry(ROTEMⓇ)values for the diagnosis of coagulopathy, prediction and guidance of blood transfusion and prediction of mortality in trauma patients" 24 : 114-, 2016
• 234 Mallaiah S, "A reply" 70 : 760-761, 2015
• 235 Leahy MF, "A pragmatic approach to embedding patient blood management in a tertiary hospital" 54 : 1133-1145, 2014
• 236 Buscher H, "A pilot, randomised controlled trial of a rotational thromboelastometry-based algorithm to treat bleeding episodes in extracorporeal life support: the TEM Protocol in ECLS Study (TEMPEST)" 19 (19): 29-36, 2017
• 237 Mehaffey JH, "A new intraoperative protocol for reducing perioperative transfusionsin cardiac surgery" 104 : 176-181, 2017
• 238 Schenk B, "A comparison of the new ROTEMⓇ sigma with its predecessor, the ROTEMdelta" 74 : 348-356, 2019
• 239 Pagano D, "2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery" 53 : 79-111, 2018
• 240 Inaba K, "2014 Consensus conference on viscoelastic test-based transfusion guidelines for early trauma resuscitation : report of the panel" 78 : 1220-1229, 2015