성인여자의 Testosterone 활성도에 관한 연구 = A Study on the Testosterone Activity in Adult Female

다국어 초록 (Multilingual Abstract)

ln order to evaluate the testosterone activities in reproductive women at different ages and postmenopausal women. the plasma testosterone concentration was measured by radioimmunoassay and binding site concentration of TEBG was analyzed by means of ammonium sulphate precipitation method. The percent testosterone free from TEBG was figured out using Rosenthal`s nomogram and free testosterone index was calculated as the product of the total testosterone concentration and the percentage of testosterone free from TEBG. Differences of active testosterone level between young female and aged reproductive women and between reproductives and postmenopausal women were compared. Cyclic pattern of testosterone activity during menstrual cycle was also checked of the women at reproductive age. Followings were the results; 1. There was no significant fluctuation in the binding site concentration of TEBG in peripheral plasma during the menstrual cycle of the normal reproductive women. But the concentration in women varied somewhat according to their ages; the concentration was noted lowest in young reproductive female and it clevated significantly after the age of fourty, followed by a slight decrease after the meno-pause. 2. Only a decreasing trend in total plasma testosterone concentration with progress of age was observed with wide individual variation. 3. The total concentration of plasma testosterone did not shows any change during menstrual cycle for either young female or aged women . Whereas, for whole reproductive women, small but significant elevation of the concentration was observed in the late follicular phase. 4. Percent testosterone free from TEBG were succesively lower in young women. aged reproductive women and postmenopausal women. 5. Percent testosterone free from TEBG remained constant throughout the cycle although the percent showed in the late follicular phase tended to be higher than the early follicular phase. 6. Although there was no definit changes in free testosterone index in accordance with the age or the cycle, the index tended to decrease with progress of age and to decrease with advance of follicle maturation by the mean values being comparable each other. 7. From above results, followings were suggested. A) A decreasing trend in testosterone actiⅵty wlth progress of age, even in reproductive stage, was induced by elevation of the binding site concentration of TEBG rather than decrease of the concentration of total testosterone. B) Cyclic changes of the plasma concentration of total testosterone could not provide any change in testosterone activity during menstrual cycle.