惡性腫瘍 및 TSH가 甲狀腺의 沃素代謝에 미치는 影響 = The Effects of a Malignant Tumor and TSH on Thyroidal Iodine Metabolism in the Rat
저자
金倬 (友石大學敎 醫科大學 放射線科學敎室)
발행기관
학술지명
권호사항
발행연도
1970
작성언어
Korean
KDC
510.000
자료형태
학술저널
수록면
619-628(10쪽)
제공처
The effects of malignant tumors on the synthesis of thyroid hormone have not been fully clarified yet, though some observes shown that the thyroidal iodine uptake rate is decreased and deiodination of thyroxine increases in both man and rats bearing malignant tumors. Most of such reports came from the observations made merely by giving a single tracer dose of ^(131)I or tagged thyroid hormone.
It is felt very difficult to determine factual concentration of the iodide in a complicated iodide pool through such experiments, and moreover when the distribution and the quantity of total body fluid are scverely impeded, an erroneous conclusion may be incurred. On the other hand, there have appeared many reports concerning the effects of thyroid stimulating hormone on the physiology and morphology of the thyroid gland, but there have been very few works on the early effects of TSH upon the thyroid gland in respect to the synthesis of the thyroid hormone thus far.
This study was undertaken to observe the metabolic process of the thyroid hormone and early effects of TSH or the synthesis of the thyroid hormone with double tracing method in normal and tumor-bearing rats. Ascites hepatoma was transplanted to 25 rats weighing from 150 to 200 grams, and 17 rats which developed a moderate amount of ascites were selected as tumor-bearing experimantal animals. The rats were allowed to drink water containing 4 μCi of Na^(131)I per 10㎍. on their will for a week (about 10㎍ a week). The rats were killed 3 hours after intravenous administration of 3 μCi of carrier-free Na^(131)I. The activities of ^(131)I and ^(123)I of the thyroid homogenates and urine were measured, and total iodide contents and uptake rates of the thyroid glands were calculated from the radioactivities thus obtained. On the other hand, various doses from 1 to 6 units of TSH were given intravenously at various times prior to administration of ^(131)I to both normal and tumor-bearing groups, then the rats were killed at various time intervals. The removed thyroid glands were placed into the test tubes which contained 100㎍. of thiouracil and phosphate buffer (pH 8.5), and then the thyroidal iodine uptake rates were calculated from the radioactivites measured by scintillation counter. The concentration of inorganic iodide was determined with the thyroid homogenates by means of paper electrophoresis. Thereafter, the glands were digested with pancreatin, and analysis of the fractions of radioiodinated organic compounds was made employing ascending paper filter chromatography.
The results obtained are summarized as follows.
1. There was no significant difference in the total iodine concentrations between normal and tumor-bearing group, but the thyroidal iodine uptake rate was profoundly decreased in the rats bearing an experimentally induced malignant tumor.
2. It took approximately 4 hours to enhance 3-hour thyroidal ^(131)I uptake rate by TSH, and for the first 2 hours TSH significantly suppressed the uptake rate. In tumor-bearing groups, no such phenomenon was manifested until 6 hours after administration of TSH, but the iodine uptake rate was elevated slowly 8 hours later.
3. When TSH and ^(131)I were given simultaneously, the thyroidal ^(131)I uptake rates were not appreciably different from those in the control group, to which ^(131)I was given alone.
4. TSH promoted the synthesis of thyronines, while it inhibited formation of diiodotyrosine. These changes seemed to take place within an hour, and it was thus felt that TSH stimulated synthesis and utilization of thyroid hormones.
5. The serum protein-bound iodine was significantly diminished in the tumor-bearing rats. This was considered to be caused by decreased secretion of TSH secondary to a malignant neoplasm.
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