定癎丸의 抗癎疾性 效果에 대한 實驗的 硏究 = An Experimental Study on the Antipileptic Effects of Jeongganhwan

국문 초록 (Abstract)

이 실험은 정간환의 진경효과，강온효과，진통효과，진정효과, GABAergic SYSTEM에 미치는 영향 등을 조사하기 위한 것으로 아래와 같은 결론을 얻었다.
1. 정간환 추출액은 strychine에 의해 유발된 경련의 유발 시간을 연장시켰다.
2. 정간환 추출액은 ECT unit의 전기충격에 의해 유발된 경련으로 인한 사망시간을 연장시켰다.
3. 정간환 추출액은 정상체온 및 endotoxin에 의해 유발된 발열에 대해 강온효과가 있었다.
4. 정간환 추출액은 acetic acid 주입에 의한 진통실험에서 writhing syndrome의 횟수를 감소시켰다.
5. 정간환 추출액은 자발운동을 감소시켰다.
6. 정간환 추출액은 뇌의 GABA-T의 활성을 감소시켰다.
7. 정간환 추출액은 뇌의 GABA 활성농도를 증가시켰다.
8. 정간환 추출액은 뇌의 GAD 활성도를 증가시켰다.

다국어 초록 (Multilingual Abstract)

This study has been carried out to investigate the effects of Jeonggan hwan(JGH) extracts on anti-convulsive, antipyretic, analgesic, sedative and GABAergic system of experimental animals. The results of this study were as follows:
1. JGH extract prolonged significantly the beginning time to convulsion and death induced by strychnine.
2. JGH extract prolonged significantly the time to death induced by electrical shock of ECT unit,(3 sec, 200 F, 25 mA)
3. On the experiment of hypothermic effects of JGH extract on the rectal temperature of mice, JGH extract decreased significantly the rectal temperature of mice
4. On the experiment of antipyretic effects of JGH extract on the febrile induced by the subcutaneous injection of 150 ㎍/㎏ endotoxin in mice, JGH extract decreased significantly the rectal temperature of mice.
5. On the experiment of analgesic effects of JGH extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1 ml/100g in mice, the writhing syndrome induced by acetic acid was reduced significantly by administration of JGH extract.
6. On the experiment of effects of JGH extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of JGH extract .
7. On the experiment of effects of JGH extract on the activity of GABA - transaminase (GABA-T) in mouse brains after 21 days of oral administration of JGH extract, the activity of GABA-T was reduced significantly by administration of JGH extract.
8. On the experiment of effects of JGH extract on the activity concentration of GABA in mouse brain after 21 days of oral administration of JGH extract, the activity concentration of GABA was reduced significantly by administration of JGH extract.
9. On the experiment of effect of JGH water extract on the activity of GAD in mouse brains after 21 days of oral administration of JGH extract, the activity of GAD was reduced significantly by administration of JGH extract. According to the these results, Jeongganhwan extracts reveal the effects on the anti-convulsive, antipyretic, analgesic, sedative and GABAergic system.